Results 1 to 10 of about 27,469 (292)

“Abraxane‐Like” Radiosensitizer for In Situ Oral Cancer Therapy [PDF]

Advanced Science
Radiotherapy plays a vital role in cancer therapy. However, the hypoxic microenvironment of tumors greatly limits the effectiveness, thus it is crucial to develop a simple, efficient, and safe radiosensitizer to reverse hypoxia and ameliorate the ...
Zijian Gong, Yixuan Fu, Yuan Gao, Fei Jiao, Qinzhi Su, Xiao Sang, Binglin Chen, Xuliang Deng, Xinyu Liu   +8 more
exaly   +4 more sources

MKI-1, a Novel Small-Molecule Inhibitor of MASTL, Exerts Antitumor and Radiosensitizer Activities Through PP2A Activation in Breast Cancer

Frontiers in Oncology, 2020
Although MASTL (microtubule-associated serine/threonine kinase-like) is an attractive target for anticancer treatment, MASTL inhibitors with antitumor activity have not yet been reported.
Ah-Young Kim, Yi Na Yoon, Yi Na Yoon, Jiyeon Leem, Jee-Young Lee, Kwan-Young Jung, Minsung Kang, Jiyeon Ahn, Sang-Gu Hwang, Jeong Su Oh, Jae-Sung Kim, Jae-Sung Kim   +11 more
doaj   +2 more sources

RRx-001, A novel dinitroazetidine radiosensitizer [PDF]

Investigational New Drugs, 2016
The 'holy grail' in radiation oncology is to improve the outcome of radiation therapy (RT) with a radiosensitizer-a systemic chemical/biochemical agent that additively or synergistically sensitizes tumor cells to radiation in the absence of significant ...
Bryan Oronsky, Jan Scicinski, Pedro J Cabrales   +2 more
exaly   +3 more sources

Fluorescent Gold Nanoparticles in Suspension as an Efficient Theranostic Agent for Highly Radio-Resistant Cancer Cells

Journal of Nanotheranostics, 2023
Gold nanoparticles are a promising candidate for developing new strategies of therapy against cancer. Due to their high atomic number and relative biocompatibility, they are commonly investigated as radiosensitizers to locally increase the dose of ...
Sarah Vogel, Alice O’Keefe, Léa Seban, Michael Valceski, Elette Engels, Abass Khochaiche, Carolyn Hollis, Michael Lerch, Stéphanie Corde, Christophe Massard, Komla Oscar Awitor, Moeava Tehei   +11 more
doaj   +1 more source

ANTP-SMACN7 fusion peptide alone induced high linear energy transfer irradiation radiosensitization in non-small cell lung cancer cell lines

Cancer Biology & Medicine, 2022
Objective: The aim of the present study was to investigate the mechanisms responsible for the radiation-sensitizing effect of antennapedia proteins, ANTP-SMACN7, on lung cancer cells treated with accelerated carbon and Fe particle irradiation.
Yi Xie, Bing Wang, Liqing Du, Yan Wang, Chang Xu, Hong Zhang, Kaixue Wen, Qiang Liu, Takanori Katsube   +8 more
doaj   +1 more source

Valproic Acid-Mediated Reduction of DNA Double-Strand Break Reparation Capacity of Irradiated MCF-7 Cells [PDF]

Iranian Journal of Medical Physics, 2016
Introduction H istone deacetylase inhibitors (HDIs), as  radiation sensitizing agents, are considered as a novel class of anti-cancer factors, which are studied in various tumor cell-lines.
Ahmad yarmohamadi, Jahanbakhsh Asadi, Alireza Khoshbin khoshnazar, Mohammad Mostakhdem Hashemi   +3 more
doaj   +1 more source

mTOR Inhibitors as Radiosensitizers in Neuroendocrine Neoplasms

Frontiers in Oncology, 2021
Peptide receptor radioligand therapy (PRRT) has evolved as an important second-line treatment option in the management of inoperable and metastatic neuroendocrine neoplasms (NEN).
Samantha Exner, Gerard Arrey, Vikas Prasad, Vikas Prasad, Carsten Grötzinger, Carsten Grötzinger, Carsten Grötzinger, Carsten Grötzinger   +7 more
doaj   +1 more source

Influence of 2-Nitroimidazoles in the Response of FaDu Cells to Ionizing Radiation and Hypoxia/Reoxygenation Stress

Antioxidants, 2023
Cellular adaptations to hypoxia promote resistance to ionizing radiation (IR). This presents a challenge for treatment of head and neck cancer (HNC) that relies heavily on radiotherapy.
Faisal Bin Rashed, Wisdom Deebeke Kate, Mesfin Fanta, Leonard Irving Wiebe, Piyush Kumar, Michael Weinfeld   +5 more
doaj   +1 more source

Metallic Nanoparticles: A Useful Prompt Gamma Emitter for Range Monitoring in Proton Therapy?

Radiation, 2021
In clinical practice, dose delivery in proton therapy treatment is affected by uncertainties related to the range of the beam in the patient, which requires medical physicists to introduce safety margins on the penetration depth of the beam.
Sébastien Penninckx, Félicien Hespeels, Julien Smeets, Julien L. Colaux, Stéphane Lucas, Anne-Catherine Heuskin   +5 more
doaj   +1 more source

Interpretation of Evidence-based Guidelines on Role of Emerging and Investigational Therapies for Treatment of Adults with Metastatic Brain Tumors Published by CNS in 2019

Zhongliu Fangzhi Yanjiu, 2020
Metastatic brain tumors are the most common intracranial tumors among adults. The Congress of Neurological Surgeons(CNS) published Evidence-based Clinical Practice Parameter Guidelines for the Treatment of Patients with Metastatic Brain Tumors in 2010 ...
TANG Yunyu, FAN Cungang, LIU Ruen
doaj   +1 more source