Results 31 to 40 of about 9,097 (242)

Combining Oncolytic Adenovirus with Radiation—A Paradigm for the Future of Radiosensitization

Frontiers in Oncology, 2017
Oncolytic viruses and radiotherapy represent two diverse areas of cancer therapy, utilizing quite different treatment modalities and with non-overlapping cytotoxicity profiles.
Sean M. O’Cathail, Tzveta D. Pokrovska, Timothy S. Maughan, Kerry D. Fisher, Leonard W. Seymour, Maria A. Hawkins   +5 more
doaj   +1 more source

The combination of rosuvastatin and meloxicam enhances the radiotherapy efficacy of MCF7, T-47D, and MDA-MB-231 breast cancer cell lines

Research in Pharmaceutical Sciences
Background and purpose: Radiotherapy is an essential treatment for breast cancer, but radioresistance remains a major obstacle. Studies suggest that statins and cyclooxygenase-2 (COX-2) inhibitors can enhance radiotherapy, yet few have examined their ...
Arvin Naeimi, Hamid Saeidi Saedi, Amir Mohsen Bakhtiyari, Kimia Shabani, Zahra Babajani, Mona Haddad Zahmatkesh   +5 more
doaj   +1 more source

Alpha-Mangostin Enhances Radiosensitivity in HeLa Cervical Cancer Cells

Scientia Pharmaceutica
Radiotherapy (RT) is a standard treatment for cervical cancer, but its efficacy is often limited by tumor hypoxia and low radiosensitivity. Radiosensitizers that enhance RT without dose escalation are therefore of clinical interest. Alpha-mangostin (AM),
Pimvaree Aissara, Ausanai Prapan, Chanyatip Suwannasing   +2 more
doaj   +1 more source

Development of [131I]I-EOE-TPZ and [131I]I-EOE-TPZMO: Novel Tirapazamine (TPZ)-Based Radioiodinated Pharmaceuticals for Application in Theranostic Management of Hypoxia

Pharmaceuticals, 2019
Introduction: Benzotriazine-1,4-dioxides (BTDOs) such as tirapazamine (TPZ) and its derivatives act as radiosensitizers of hypoxic tissues. The benzotriazine-1-monoxide (BTMO) metabolite (SR 4317, TPZMO) of TPZ also has radiosensitizing properties, and ...
Hassan Elsaidi, Fatemeh Ahmadi, Leonard I. Wiebe, Piyush Kumar   +3 more
doaj   +1 more source

Matrices and Affinity Ligands for Antibody Purification and Corresponding Applications in Radiotherapy

Biomolecules, 2022
Antibodies have become an important class of biological products in cancer treatments such as radiotherapy. The growing therapeutic applications have driven a demand for high-purity antibodies. Affinity chromatography with a high affinity and specificity
Aiying Xue, Saijun Fan
doaj   +1 more source

Whole brain radiotherapy with radiosensitizer for brain metastases [PDF]

, 2009
Purpose To study the efficacy of whole brain radiotherapy (WBRT) with radiosensitizer in comparison with WBRT alone for patients with brain metastases in terms of overall survival, disease progression, response to treatment and adverse effects of ...
Sergio Luis Afonso, Fonseca Ellen, Ellen Fonseca, Stefano Eduardo, Gustavo Viani, Eduardo Jose Stefano, Viani Gustavo, Gustavo Manta, Ellen Carrara Fonseca, Gustavo Arruda Viani, Manta Gustavo, Ligia Issa De fendi, De fendi Ligia, Ligia De fendi, Eduardo Stefano, Gustavo Borges Manta, Afonso Sergio, Sergio Afonso   +17 more
core   +1 more source

Withanolide D Enhances Radiosensitivity of Human Cancer Cells by Inhibiting DNA Damage Non-homologous End Joining Repair Pathway

Frontiers in Oncology, 2020
Along with surgery and chemotherapy, radiation therapy (RT) is an important modality in cancer treatment, and the development of radiosensitizers is a current key challenge in radiobiology to maximize RT efficiency.
Jerome Lacombe, Titouan Cretignier, Laetitia Meli, E. M. Kithsiri Wijeratne, Jean-Luc Veuthey, Muriel Cuendet, A. A. Leslie Gunatilaka, Frederic Zenhausern, Frederic Zenhausern   +8 more
doaj   +1 more source

Radiosensitization and Radioprotection by Curcumin in Glioblastoma and Other Cancers

Biomedicines, 2022
Radiation therapy plays an important role in almost every cancer treatment. However, radiation toxicity to normal tissues, mainly due to the generation of reactive free radicals, has limited the efficacy of radiotherapy in clinical practice. Curcumin has
Vasiliki Zoi, Vasiliki Galani, Pericles Tsekeris, Athanasios P. Kyritsis, George A. Alexiou   +4 more
doaj   +1 more source

Combining Nanocarrier-Assisted Delivery of Molecules and Radiotherapy

Pharmaceutics, 2022
Cancer is responsible for a significant proportion of death all over the world. Therefore, strategies to improve its treatment are highly desired. The use of nanocarriers to deliver anticancer treatments has been extensively investigated and improved ...
Eliza Rocha Gomes, Marina Santiago Franco   +1 more
doaj   +1 more source

An Activity‐Reinforced P‐Modified Single‐Atom Cu Nanozyme Potentiates IDO Blockade‐Induced Tumor Radiotherapy

Advanced Science, EarlyView.
A phosphorus‐modified single‐atom copper nanozyme delivering the IDO1 inhibitor 1‐methyl‐tryptophan enhances breast cancer radioimmunotherapy by simultaneously relieving hypoxia and inducing immunogenic cell death through dual enzyme activities while blocking tryptophan metabolism to suppress regulatory T cell function.
Wei Zhao, Songliu Hu, Zhanggui Wang, Liqun Wang, Liming Zhang, Qi Li, Hua Tang, Yang Zhong, Zhongxian Zhang, Kelong Fan, Shipeng Ning, Xiyun Yan   +11 more
wiley   +1 more source