Results 31 to 40 of about 27,469 (292)

GBM radiosensitizers: dead in the water…or just the beginning? [PDF]

, 2017
The finding that most GBMs recur either near or within the primary site after radiotherapy has fueled great interest in the development of radiosensitizers to enhance local control.
Bindra, Ranjit S., Chalmers, Anthony J., Dewhirst, Mark, Evans, Sydney   +3 more
core   +1 more source

Ribonucleotide reductase inhibitors: a new look at an old target for radiosensitization

Frontiers in Oncology, 2012
Ribonucleotide reductase, the rate limiting enzyme in the synthesis and repair of DNA, has been studied as a target for inhibition in the treatment of cancer for many years.
Tobias eChapman, Timothy James Kinsella
doaj   +1 more source

DNA Dosimetry with Gold Nanoparticle Irradiated by Proton Beams: A Monte Carlo Study on Dose Enhancement

Applied Sciences, 2021
Heavy atom nanoparticles, such as gold nanoparticles, are proven effective radiosensitizers in radiotherapy to enhance the dose delivery for cancer treatment.
Ngoc Han Huynh, James C. L. Chow
doaj   +1 more source

MDM2/X Inhibitors as Radiosensitizers for Glioblastoma Targeted Therapy

Frontiers in Oncology, 2021
Inhibition of the MDM2/X-p53 interaction is recognized as a potential anti-cancer strategy, including the treatment of glioblastoma (GB). In response to cellular stressors, such as DNA damage, the tumor suppression protein p53 is activated and responds ...
Xanthene Miles, Charlot Vandevoorde, Alistair Hunter, Julie Bolcaen   +3 more
doaj   +1 more source

The role of copper in disulfiram-induced toxicity and radiosensitization of cancer cells [PDF]

, 2013
<p>Disulfiram has been used for several decades in the treatment of alcoholism. It now shows promise as an anti-cancer drug and radiosensitizer. Proposed mechanisms of action include the induction of oxidative stress and inhibition of proteasome ...
Ballangrud, Børup, Cen, Cohen, Hald, Maris, Sullivan, Yu, Yuhas   +8 more
core   +1 more source

Radiosensitization Effect of Gold Nanoparticles on Plasmid DNA Damage Induced by Therapeutic MV X-rays

Nanomaterials, 2022
Gold nanoparticles (AuNPs) can be used with megavolt (MV) X-rays to exert radiosensitization effects, as demonstrated in cell survival assays and mouse experiments.
Katsunori Yogo, Masaki Misawa, Hidetoshi Shimizu, Tomoki Kitagawa, Ryoichi Hirayama, Hiromichi Ishiyama, Hiroshi Yasuda, Satoshi Kametaka, Seiichi Takami   +8 more
doaj   +1 more source

Anti-tubulin drugs conjugated to anti-ErbB antibodies selectively radiosensitize. [PDF]

, 2016
Tumour resistance to radiotherapy remains a barrier to improving cancer patient outcomes. To overcome radioresistance, certain drugs have been found to sensitize cells to ionizing radiation (IR).
Adams, Stephen R, Advani, Sunil J, Aguilera, Joe, Cohen, Ezra EW, Crisp, Jessica L, Jones, Karra A, Lippman, Scott M, Savariar, Elamprakash N, Tsien, Roger Y, Whitney, Michael A, Yang, Howard C   +10 more
core   +1 more source

Feasibility of Photofrin II as a radiosensitizing agent in solid tumors - Preliminary results [PDF]

, 2006
Background: Photofrin II has been demonstrated to serve as a specific and selective radiosensitizing agent in in vitro and in vivo tumor models. We aimed to investigate the feasibility of a clinical application of Photofrin II.
Byrne CJ, Cohen L, Dougherty TJ, Foote CS, Gomer CJ, Kostron H, Kulka U, McDonald IJ, Miller RA, O'Hara JA, Orenstein A, Schaffer M, Schaffer M, Schaffer M, Schaffer M, Schaffer M, Schmidt-Erfurth U, Schwartz S, Schwartz S, Sessler JL, Shikowitz MJ, Stewart F, Vogeser M   +22 more
core   +1 more source

Response to “Radiation Therapeutic Gain and Asian Botanicals,” by Stephen Sagar [PDF]

, 2010
Numerous botanical agents, many of which are used in whole medical system practices (i.e. traditional Chinese medicine, Ayurvedic medicine, etc.), have been shown to exhibit radiomodifying effects on tumors and normal tissues in-vitro and invivo studies.
Lawenda, Brian D.
core   +1 more source

Inorganic Nanoparticles as Radiosensitizers for Cancer Treatment

Nanomaterials, 2023
Nanotechnology has expanded what can be achieved in our approach to cancer treatment. The ability to produce and engineer functional nanoparticle formulations to elicit higher incidences of tumor cell radiolysis has resulted in substantial improvements ...
Balaashwin Babu, Samantha Archer Stoltz, Agastya Mittal, Shreya Pawar, Elayaraja Kolanthai, Melanie Coathup, Sudipta Seal   +6 more
doaj   +1 more source