Results 91 to 100 of about 5,827,231 (253)
FEBS Open Bio, EarlyView.The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez +4 more
wiley +1 more source
Impact of ct tube voltage and anode current on pet/ct image quality a NEMA IQ Phantom Study [PDF]
Nuclear Technology and Radiation ProtectionPositron emission tomography/computer tomography is a crucial modality for the quantification of metabolic activity and anatomical structure. Reducing radiation dose, especially in repeated imaging, remains a significant challenge.
Čavlin Milana +2 more
doaj +1 more source
FEBS Open Bio, EarlyView.The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen +8 more
wiley +1 more source
FEBS Open Bio, EarlyView.Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata +3 more
wiley +1 more source
Journal of Medical Signals and Sensors, 2018 Computed tomography coronary angiography (CTCA) has generated a great interest over the past two decades, due to its high diagnostic accuracy and efficacy in the assessment of patients having coronary artery disease.
Mohammadbagher Tavakoli +3 more
doaj
FEBS Open Bio, EarlyView.Functional screening identified PcSyn14890, a cyanobacteria‐specific protein that enhances growth and stress resistance in E. coli and Synechocystis PCC6803. Although we expected it to function as a molecular chaperone, it was unable to protect against thermal aggregation of GAPDH.
Akiyo Yamada +7 more
wiley +1 more source
Dr. Sulaiman Al Habib Medical JournalObjective: This study aimed to compare the effective doses among 16, 64, and 128-slice computed tomography (CT) scanners. Several strategies have been implemented to reduce the radiation dose from CT, including a low tube voltage, a high pitch protocol ...
Mansour Al Moudi +3 more
doaj +1 more source
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
Emotion finds a way to users from designers: assessing product images to convey designer's emotion [PDF]
, 2012 Along with a growing interest in emotional design and pleasurable products, it is necessary to understand how designers are able to maintain emotional impacts of their design solutions throughout the design process, and how these solutions can find a way
AOUSSAT, Améziane +4 more
core +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Stereoelectroencephalography‐guided radiofrequency thermocoagulation (SEEG‐RFTC) has emerged as a safe and effective minimally invasive treatment for children with drug‐resistant focal epilepsy. Although evidence from real‐world studies remains limited, numerous pediatric cases have demonstrated promising outcomes. This retrospective
Weitao Chen +7 more
wiley +1 more source