Results 81 to 90 of about 241,427 (245)

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

KDAC6 alters cell morphology and motility through positive and negative modulation of F‐actin distribution

FEBS Open Bio, EarlyView.
KDAC6 has been associated with cell motility and actin structures, but specific domain contributions are not established. The two catalytic domains have differential effects on motility and F‐actin regulation, affecting cortical F‐actin density, motility, stress fibers, and cell spreading.
Taylor V. Joseph, Andrea B. Pham, Kiara E. Bornes, Razan H. Hammad, Chelsea A. Rousseve‐Ross, Thomas M. Huckaba, Terry J. Watt, Tasha B. Toro   +7 more
wiley   +1 more source

Assessment of Effective Dose Associated with Coronary Computed Tomography Angiography in Isfahan Province, Iran

Journal of Medical Signals and Sensors, 2018
Computed tomography coronary angiography (CTCA) has generated a great interest over the past two decades, due to its high diagnostic accuracy and efficacy in the assessment of patients having coronary artery disease.
Mohammadbagher Tavakoli, Reihane Faraji, Zahra Alirezaei, Zohre Nateghian   +3 more
doaj  

BETTER ESTIMATING RADIATION EFFECTIVE DOSE FROM CARDIAC COMPUTED TOMOGRAPHY (CT): A COMPREHENSIVE EXAMINATION OF THE RELATIONSHIP BETWEEN EFFECTIVE DOSE AND DOSE-LENGTH PRODUCT

Journal of the American College of Cardiology, 2016
Radiation from CT is commonly quantified in term of effective dose (ED), estimated by multiplying the scanner reported dose-length product (DLP) by a conversion factor, referred to as the k factor. Current guidelines suggest a k factor of 0.014 mSv·mGy-1cm-1 for chest CT.
Sigal Trattner, Sandra Halliburton, Carla Thompson, Anjali Chelliah, Yanping Xu, Sachin Jambawalikar, M. Robert Peters, Munir Ghesani, James Jang, Udo Hoffmann, David J. Brenner, Andrew Jeffrey Einstein   +11 more
openaire   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

A Comparison of Effective doses for the 16, 64, and 128-slice Computed Tomography Scanners: A First Health Cluster Study in Riyadh

Dr. Sulaiman Al Habib Medical Journal
Objective: This study aimed to compare the effective doses among 16, 64, and 128-slice computed tomography (CT) scanners. Several strategies have been implemented to reduce the radiation dose from CT, including a low tube voltage, a high pitch protocol ...
Mansour Al Moudi, Sultan Al Dosari, Abdullah Ibrahim Al Hussain, Mazen Abounassif   +3 more
doaj   +1 more source

Effective Dose to Dose-Length Product Coefficients for Calculation of CT Effective Dose [PDF]

Radiology, 2009
Razvan C. Opreanu, Ranji Samaraweera, John P. Kepros   +2 more
openaire   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

FEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez, Juliette K. Tinker, Teresa Frisan, Taj Azarian, Ken Teter   +4 more
wiley   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source