Results 61 to 70 of about 5,827,231 (253)

Estimation of the effective dose in torso 18F-fluorodeoxyglucose PET/CT: an analysis of real-world clinical data from 51,784 patient scans

EJNMMI Physics
Background Large-scale estimation of effective dose (ED) for positron emission tomography (PET)/computed tomography (CT) remains limited. This study aimed to determine the ED of torso 18F-fluorodeoxyglucose (FDG) PET/CT using extensive real-world ...
Jeongryul Ryu, Jungsu S. Oh, Yong-il Kim, Sangwon Han, Jae Seung Kim, Kyung-Hyun Do, Jin-Sook Ryu   +6 more
doaj   +1 more source

Optimizing Radiation Dose in High-Resolution Chest CT: The Impact of Patient-Specific Factors and Size-Specific Dose Estimates

Diagnostics
Background/Objectives: High-resolution chest computed tomography (HRCT) is a critical diagnostic tool, but radiation dose optimization remains a significant concern.
Mohamed Abuzaid
doaj   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Radiation dose metrics in multidetector computed tomography examinations: A multicentre retrospective study from seven tertiary care hospitals in Kerala, South India

Indian Journal of Radiology and Imaging, 2018
Background: Presently, computed tomography (CT) is the most important source of medical radiation exposure. CT radiation doses vary considerably across institutions depending on the protocol and make of equipment.
Binoj Varghese, Indu Kandanga, Paul Puthussery, Dhanesh Vijayan, S P Harish Babu, M K Aneesh, Muhammad Noufal, E V Binu, Arun C Babu, Sheen M James, Siva Kumar   +10 more
doaj   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Patient factors associated with SSRI dose for depression treatment in general practice:A primary care cross sectional study [PDF]

, 2014
Background: Antidepressant prescribing continues to rise. Increased long-term prescribing and higher doses are contributing to current growth; however, patient factors associated with the use of higher doses remain unknown.
Brian Williams, Dougall, Nadine J., Chris F Johnson, Buchanan, Alasdair I, Stephen A MacGillivray, MacGillivray, Stephen A, Dougall, Nadine J, Buchanan, Alasdair I., Dougall, Nadine, Nadine J Dougall, Hassett, Richard D, Johnson, Chris F, Williams, Brian, Johnson, Chris F., Hassett, Richard D., MacGillivray, Stephen A.; id_orcid, Alasdair I Buchanan, MacGillivray, Steve, Richard D Hassett   +18 more
core   +2 more sources

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Versatile vector tools for efficient protein screening across multiple expression systems

FEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu, Yaqing Liu, Lei Qin, Feng Yu, Qisheng Wang, Yahui Liu   +5 more
wiley   +1 more source

Correlation between Body Mass Index and Radiation Dose Metrics in Adult Thorax and Abdomen Computed Tomography Examination: A Cross-sectional Study [PDF]

Journal of Clinical and Diagnostic Research
Introduction: Computed Tomography (CT) procedures contribute significantly to medical radiation exposure and therefore necessitate the implementation of optimisation measures that balance diagnostic image quality with patient safety. Body Mass Index (BMI)
Pritee Prachee Pradhan, Maajid Mohi Ud Din Malik   +1 more
doaj   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source