Results 61 to 70 of about 241,427 (245)

TOWARD NATIONAL CT DIAGNOSTIC REFERENCE LEVELS IN THE UNITED ARAB EMIRATES: A MULTICENTER REVIEW OF CT DOSE INDEX AND DOSE LENGTH PRODUCT

Radiation Protection Dosimetry, 2020
Abstract This multicenter study evaluated computed tomography dose index volume (CTDIvol) and dose length product (DLP) to contribute to establishing computed tomography (CT) national diagnostic reference levels (NDRLs) in the United Arab Emirates (UAE).
Mohamed M Abuzaid, Wiam Elshami, A El Serafi, T Hussien, J R McConnell, H O Tekin   +5 more
openaire   +2 more sources

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Establishment of diagnostic reference levels in computed tomography for select procedures in Pudhuchery, India

Journal of Medical Physics, 2014
Computed tomography (CT) scanner under operating conditions has become a major source of human exposure to diagnostic X-rays. In this context, weighed CT dose index (CTDI w ), volumetric CT dose index (CTDI v ), and dose length product (DLP) are ...
A Saravanakumar, K Vaideki, K N Govindarajan, S Jayakumar   +3 more
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Proposing Multiregional Diagnostic Reference Levels for Common CT Angiography Examinations in Saudi Arabia

Diagnostics
Objectives: Diagnostic reference levels (DRLs) are crucial tools for optimizing radiation exposure during different radiological examinations. This study aimed to establish preliminary DRLs for commonly performed computed tomographic angiography (CTA ...
Ali Alhailiy, Essam Alkhybari, Mohammed Alshuhri, Abdullah Al-Othman, Tarek Hegazi, Mohammed Alsuhaimi, Sultan Alghamdi, Khaled Alenazi, Yazeed Alashban, Sami Alghamdi, Omar Quzi, Osama Jaafari, Saleh Alajlani, Abdulrahman Masmali, Yasser Hadi, Elbagir Manssor, Mustafa Mahmoud   +16 more
doaj   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Improving the approach to calculating shielding in computed tomography rooms

Радиационная гигиена
The study assessed the acceptability of the currently existing approach to calculating shielding in computed tomography rooms and formulated proposals for its improvement, taking into account the parameters of research in domestic medical practice. It is
P. S. Druzhinina, L. A. Chipiga, V. Yu. Golikov, A. V. Vodovatov, S. Yu. Bazhin, E. N. Shleenkova, G. V. Berkovich, I. V. Soldatov, Z. A. Lantukh, K. V. Tolkachev   +9 more
doaj   +1 more source

Correlation between Body Mass Index and Radiation Dose Metrics in Adult Thorax and Abdomen Computed Tomography Examination: A Cross-sectional Study [PDF]

Journal of Clinical and Diagnostic Research
Introduction: Computed Tomography (CT) procedures contribute significantly to medical radiation exposure and therefore necessitate the implementation of optimisation measures that balance diagnostic image quality with patient safety. Body Mass Index (BMI)
Pritee Prachee Pradhan, Maajid Mohi Ud Din Malik   +1 more
doaj   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source