Results 41 to 50 of about 5,827,231 (253)

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Evaluation of the effect of the introduction of iterative reconstruction (iDose) on dose length product (mGy.cm) and effective dose (mSv) across CT protocols.

, 2015
1Dose length product, measured in mGy.cm2Effective dose calculated using ImPACT in mSv3Mean rank of DLP / Effective Dose before and following iDose. using the Mann Whitney U test (a rank-order (or nonparametric test) which assesses whether the before and
David A. J. Gibson (570345), Richard Fox (153532), Rene K. Forsyth (570346), Rachael E. Moorin (314872)   +3 more
core   +1 more source

Comparing Radiation Doses in CBCT and Medical CT Imaging for Dental Applications

Journal of Pharmacy and Bioallied Sciences
BackgroundDental imaging plays a crucial role in diagnosis and treatment planning, with cone-beam computed tomography (CBCT) and medical computed tomography (CT) being two common modalities.
Jain Sulabh, Sarah, Mishra Shweta, Saleem Sumera, Vijayan Anu   +4 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Complexity of Constraint Satisfaction Problems over Finite Subsets of Natural Numbers [PDF]

, 2016
We study the computational complexity of constraint satisfaction problems that are based on integer expressions and algebraic circuits. On input of a finite set of variables and a finite set of constraints the question is whether the variables can be ...
Dose, Titus
core   +1 more source

An Analysis of Computed Tomography Diagnostic Reference Levels in India Compared to Other Countries

Diagnostics
Computed Tomography (CT) is vital for diagnosing and monitoring medical conditions. However, increased usage raises concerns about patient radiation exposure. Diagnostic Reference Levels (DRLs) aim to minimize radiation doses in CT imaging.
Maajid Mohi Ud Din Malik, Mansour Alqahtani, Ibrahim Hadadi, Abdullah G. M. AlQhtani, Abdullah Alqarni   +4 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

P-Optimal Proof Systems for Each NP-Set but no Complete Disjoint NP-Pairs Relative to an Oracle [PDF]

, 2019
Pudlák [P. Pudlák, 2017] lists several major conjectures from the field of proof complexity and asks for oracles that separate corresponding relativized conjectures.
Dose, Titus
core   +1 more source