Results 51 to 60 of about 5,827,231 (253)

Advanced Computational Methods for Radiation Dose Optimization in CT

Diagnostics
Background: In planning radiotherapy treatments, computed tomography (CT) has become a crucial tool. CT scans involve exposure to ionizing radiation, which can increase the risk of cancer and other adverse health effects in patients.
Shreekripa Rao, Krishna Sharan, Srinidhi Gururajarao Chandraguthi, Rechal Nisha Dsouza, Leena R. David, Sneha Ravichandran, Mubarak Taiwo Mustapha, Dilip Shettigar, Berna Uzun, Rajagopal Kadavigere, Suresh Sukumar, Dilber Uzun Ozsahin   +11 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Computed tomography dose index and dose length product for cone-beam CT: Monte Carlo simulations.

, 2019
Dosimetry in kilovoltage cone beam computed tomography (CBCT) is a challenge due to the limitation of physical measurements. To address this, we used a Monte Carlo (MC) method to estimate the CT dose index (CTDI) and the dose length product (DLP) for a ...
Kim, Sangroh, Yin, Fang-Fang, Song, Haijun, Yoshizumi, Terry T, Samei, Ehsan   +4 more
core   +1 more source

Establishment of Local Diagnostic Reference Levels for Pediatric Head CT at a South African Tertiary Hospital

Brazilian Journal of Radiation Sciences
Computed tomography (CT) provides rapid, high-resolution 3D imaging, reducing motion artifacts and the need for sedation in pediatric patients. However, children are highly sensitive to ionizing radiation due to their developing tissues and longer life ...
Mpumelelo Nyathi, Autherlia Dimpho Rinkie Mosiame   +1 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Dose-related hypoglycemia in venlafaxine poisoning: a retrospective cohort study

, 2022
Several case reports describe hypoglycemia in the context of venlafaxine overdose, while investigations at therapeutic dose suggested a neutral effect on glucose homeostasis. Studies on hypoglycemia in venlafaxine intoxication are lacking.
Florian Eyer (4536688), Elias Bekka (9436061)   +1 more
core   +1 more source

Changes in the Diagnostic Reference Levels for Computed Tomography in Japan: A Literature Review to Guide Future Revisions [PDF]

Journal of Radiation Protection and Research
Radiation is widely used in medicine but has both benefits and risks. Three important points must be taken into account in the medical use of radiation: justification, optimization, and dose limits.
Teruo Ito
doaj   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

A survey of computed tomography dose index and dose length product level in usual computed tomography protocol [PDF]

, 2018
Background: Nowadays, the use of computed tomography (CT) as a diagnostic tool has been considerably increased. Therefore, implementation of the program to conform the protection regulations on the CT scan is necessary to reduce the detrimental ...
Mihandoost, E., Mohseni, M., Aliasgharzadeh, A.   +2 more
core  

Dose-time test

, 2016
Mean length of C. aspersum’s diverticulum over time when four doses of love-dart mucus of the species E.
Joris M. Koene (250439), Monica Lodi (3322374), Koene, Joris M., Lodi, Monica   +3 more
core   +1 more source