Pharmacology Research and Perspectives, 2019 This study aimed to investigate the pharmacokinetic and pharmacodynamic (PK/PD) profiles of dotinurad, a novel uricosuric agent, and to construct a PK/PD model to predict serum urate (SUA) levels after dotinurad administration in healthy men. PK/PD model
Keisuke Motoki +2 more
exaly +4 more sources
Efficacy and safety of switching from febuxostat to dotinurad, a novel selective urate reabsorption inhibitor, in hyperuricemic patients with type 2 diabetic kidney disease: Protocol for a single-arm, open-label, prospective, exploratory study [PDF]
Frontiers in Endocrinology, 2023 BackgroundDotinurad is a novel uricosuric drug in Japan with selective and potent urate transporter 1 (URAT1) inhibitory activity. This study aims to evaluate the efficacy and safety of dotinurad in hyperuricemic patients with type 2 diabetic kidney ...
Takeshi Osonoi +5 more
doaj +3 more sources
Effect of Dotinurad on Uric Acid and Hepatorenal Parameters in Steatotic Liver Disease: A Pilot Study in Japanese Patients [PDF]
BiomedicinesBackground: Dotinurad (DOT) has demonstrated beneficial metabolic effects in preclinical models as a selective uric acid reabsorption inhibitor. However, its clinical impact on steatotic liver disease (SLD) with hyperuricemia (HU-SLD) remains unclear ...
Yuma Kamijo +9 more
doaj +3 more sources
Dotinurad Treatment for Patients With Hyperuricemia Complicating CKD [PDF]
Kidney International ReportsIntroduction: The management of hyperuricemia is important to reduce cardiovascular risk and the progression of renal injury in chronic kidney disease (CKD).
Katsuyuki Tanabe +11 more
doaj +4 more sources
Dotinurad, a Novel Urate Reabsorption Inhibitor, Prolongs Survival in Alport Mice [PDF]
Kidney360Key Points. Dotinurad treatment slows the progression of kidney disease in a mouse model of Alport syndrome, a genetic model of CKD. Dotinurad may represent a potential therapeutic strategy for CKD management. Background.
Ryosuke Saiki +8 more
doaj +6 more sources
Molecular mechanisms of urate transport by the native human URAT1 and its inhibition by anti-gout drugs [PDF]
Cell DiscoveryGout, a common and painful disease, stems from hyperuricemia, where elevated blood urate levels lead to urate crystal formation in joints and kidneys. The human urate transporter 1 (hURAT1) plays a critical role in urate homeostasis by facilitating urate
Canrong Wu +15 more
doaj +3 more sources
Clinical and Experimental Hypertension, 2021 Background: Hyperuricemia is a risk factor for the development of hypertension and is comorbid in many hypertensive patients. According to Japanese hypertension management guidelines published in 2019, a target serum uric acid level of ≤6.0 mg/dL is ...
Toshinari Takahashi +3 more
doaj +2 more sources
The Promise of Dotinurad for Hyperuricemia in CKD [PDF]
Kidney International ReportsAmy S. Li, Pranav S. Garimella
doaj +3 more sources
Efficacy and Safety of Dotinurad in Patients With Advanced Chronic Kidney Disease [PDF]
Internal MedicineObjective Hyperuricemia is associated with cardiovascular disease and chronic kidney disease (CKD). Dotinurad is a new uricosuric drug that has not been evaluated in clinical trials in patients with advanced CKD (CKD G3b-G5).
Hirayasu Kai
exaly +3 more sources
Prospects of anti-inflammatory and urate-lowering therapy of gout: A vector from the past to the future [PDF]
Научно-практическая ревматология, 2022 The article provides an overview of new and promising drugs aimed at anti-inflammatory and urate-lowering therapy of gout, both already registered and used in clinical practice, and at the stages of implementation or clinical research and demonstrating ...
A. A. Garanin +2 more
doaj +3 more sources