Results 111 to 120 of about 89,922 (309)

OsRAD51C Is Essential for Double Strand Break Repair in Rice Meiosis

Frontiers in Plant Science, 2014
RAD51C is one of the RAD51 paralogs that plays an important role in DNA double-strand break repair by homologous recombination. Here, we identified and characterized OsRAD51C, the rice homolog of human RAD51C.
Ding eTang, Chunbo eMiao, Yafei eLi, Hongjun eWang, Xiaofei eLiu, Hengxiu eYu, Zhukuan eCheng   +6 more
doaj   +1 more source

Microgel‐Based 3D Bioprinting: A Convergent Strategy Integrating Material Design, Jamming Dynamics, and Biological Function

Advanced Healthcare Materials, EarlyView.
Microgel‐based 3D printed constructs represent a compelling and versatile innovation for engineering architecturally complex, dynamically remodelable, and biocompatible structures with high structural fidelity and bioactivity. By integrating material design, biofabrication, and biological function, these systems enable the development of adaptive ...
Elena Ghighină, Andreea Ioana Dinu, Jana Ghițman   +2 more
wiley   +1 more source

Collaboration and competition between DNA double-strand break repair pathways

, 2010
DNA double-strand breaks resulting from normal cellular processes including replication and exogenous sources such as ionizing radiation pose a serious risk to genome stability, and cells have evolved different mechanisms for their efficient repair.
Kass, Elizabeth M., Elizabeth M. Kass, Jasin, Maria, Maria Jasin   +3 more
core   +1 more source

DNA Repair: A RIDDLE at a Double-Strand Break [PDF]

Current Biology, 2009
Ubiquitin is known to accumulate at the sites of DNA damage. The identification of a new ubiquitin ligase, RIDDLIN, provides evidence for a ubiquitin-signalling cascade that regulates the assembly of an important DNA repair complex at a DNA double-strand break.
openaire   +3 more sources

Natural Biomaterials for Osteochondral Repair: From Source to Strategy

Advanced Healthcare Materials, EarlyView.
Biological origin‐guided overview of natural biomaterials and therapeutic strategies for osteochondral tissue engineering. The circular diagram categorizes representative materials and strategies into plant/algae‐derived, microbial‐derived, animal‐derived, and human‐derived sources, centered on an osteochondral defect repair model.
Hengyu Liu, Hanyang Zhang, Wenbo Yang, Hao Chen, Jincheng Wang, Fei Chang   +5 more
wiley   +1 more source

Targeting BRCA1-BER deficient breast cancer by ATM or DNA-PKcs blockade either alone or in combination with cisplatin for personalized therapy [PDF]

, 2014
BRCA1, a key factor in homologous recombination repair may also regulate base excision repair (BER). Targeting BRCA1-BER deficient cells by blockade of ATM and DNA-PKcs could be a promising strategy in breast cancer.
Seedhouse, Claire, Russell, R, Moseley, P, Arora, A., Agarwal, D., Russell, R., Chan, Stephen, Green, A, Albarakati, N, Rakha, E.A., Abdel-Fatah, TMA, Caldas, C, Ellis, IO, Moseley, P., Rakha, Emad A., Albarakati, Nada, Doherty, Rachel, Chan, S., Perry, Christina, Seedhouse, C, Alsubhi, N., Ball, G., Moseley, Paul, Agarwal, D, Perry, C., Arora, Arvind, Alsubhi, N, Doherty, R, Arora, A, Russell, Roslin, Ball, G, Albarakati, N., Green, Andrew, Ball, Graham, Abdel-Fatah, Tarek M.A., Rakha, EA, Caldas, Carlos, Caldas, C., Ellis, I.O., Alsubhi, Nouf, Agarwal, Devika, Abdel-Fatah, T.M.A., Seedhouse, C., Chan, S, Doherty, R., Madhusudan, Srinivasan, Perry, C, Madhusudan, S, Green, A., Madhusudan, S., Ellis, Ian O.   +50 more
core   +1 more source

Mechanically Programmable DNA Hydrogel Microparticles for 3D Cellular Systems

Advanced Materials, EarlyView.
DNA hydrogel microparticles are designed to exhibit controllable viscoelasticity and stiffness across three orders of magnitude from 30Pa$30 \,\mathrm{Pa}$ to 6.5kPa$6.5 \,\mathrm{kPa}$. They are uptaken into fibroblast spheroids where they are actively remodeled by cellular forces depending on their mechanical properties.
Tobias Walther, Eleni Dalaka, Gotthold Fläschner, Manuel Gómez‐González, Ilia Platzman, Sadaf Pashapour, Michelle Emmert, Pere Roca‐Cusachs, Xavier Trepat, Kerstin Göpfrich   +9 more
wiley   +1 more source

Somatic role of SYCE2: an insulator that dissociates HP1α from H3K9me3 and potentiates DNA repair

Life Science Alliance, 2018
This study reveals that the synaptonemal complex protein SYCE2 potentiates ataxia telangiectasia mutated–mediated DNA double-strand break repair by dissociating HP1α from trimethylated histone H3 lysine 9 in somatic cells.
Noriko Hosoya, Masato Ono, Kiyoshi Miyagawa   +2 more
doaj   +1 more source

Stable Protein‐Based G‐Quadruplex‐Derived Supramolecular Bioinks as Tunable ECM‐Mimetic Constructs Assembled by Combining Non‐Covalent and Covalent Strategies

Advanced Materials, EarlyView.
Harnessing the synergistic interplay of supramolecular self‐assembly, under macromolecular crowding conditions, and enzymatic‐mediated covalent crosslinking toward a stable protein‐based G‐quadruplex‐derived supramolecular bioink. This bioinspired strategy enables the biofabrication of complex and tunable ECM‐mimetic constructs, providing a platform ...
Vera Sousa, Rita Sobreiro‐Almeida, Bart W. L. van den Bersselaar, E. W. Meijer, Ghislaine Vantomme, João Borges, João F. Mano   +6 more
wiley   +1 more source

Analysis of telomere maintenance in artemis defective human cell lines [PDF]

, 2009
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Telomeres are physical ends of chromosomes consisting of (TTAGGG)n DNA sequence and a specialized set of proteins that protect chromosomal ends from ...
Yasaei, Hemad
core