Results 61 to 70 of about 322,075 (306)
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Coupled–Channels Analyses For Heavy–Ion Fusion Reactions of 16O+92Zr,144,148Sm Systems
Atom Indonesia, 2010 We study in detail the fusion reaction of 16O with 92Zr and 144,148Sm at sub-barrier energies with coupled-channels framework using the error function potential for the nuclear potential.
M. Zamrun , K. Hagino
doaj +1 more source
On risk processes with double barriers
Acta et Commentationes Universitatis Tartuensis de Mathematica, 2004 We consider risk processes with two barriers. The risk process starts with an initial capital u>0 and the two barriers are set at 0 and v(>u). We are interested in finding the probability φ(u,v) that the risk process hits the upper barrier v before 0. Both cases of positive and negative relative safety loading are considered.
Lokk, Katrin, Pärna, Kalev
openaire +2 more sources
Check, Double Check: The G2 Barrier to Cancer [PDF]
Cell Cycle, 2006 Loss of the G1/S checkpoint is recognized as a mandatory step in the development of cancer. Nevertheless, both in vivo and in vitro experiments have indicated that this condition highly sensitizes cells to apoptosis, e.g., primary mouse embryonic fibroblasts that lack the complete retinoblastoma suppressor gene family (TKO MEFs) massively die under ...
Floris, Foijer, Hein, te Riele
openaire +2 more sources
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Spatial quasi-bound states of Dirac electrons in graphene monolayer
Scientific ReportsOur study investigated the emergence of spatial quasi-bound states (QBSs) in graphene monolayers induced by rectangular potential barriers. By solving the time-independent Dirac equation and using the transfer matrix formalism, we calculated the ...
Mohammed Miniya +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Double general point interactions: symmetry and tunneling times
Frontiers in Physics, 2016 We consider the one dimensional problem of a non-relativistic quantum particle scattering off a double barrier built from two generalized point interactions (each one characterized as a member of the four parameter family of point interactions).
Molly A. Lee +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source