Results 101 to 110 of about 4,907,197 (292)

The Double Effect of “Double Standards” [PDF]

Both Erosion and Strengthening of International ...
openaire   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

An effective purification of double-effect distillation for bio-based pentamethylene diisocyanate. [PDF]

RSC Adv, 2023
He F, Tang Y, Lu Z, Hu Q, Yang Y, Li G, Li H, Chen K.   +7 more
europepmc   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Thomas M. Scanlon’s Critique of the Doctrine of Double Effect: Intention and Permissibility

Studia Philosophiae Christianae
This article examines Thomas M. Scanlon’s critique of the Doctrine of Double Effect (DDE), focusing on its validity and implications for his contractualist framework.
Karol Wołk
doaj   +1 more source

Double-Effect Donation or Bodily Respect? A "Third Way" Response to Camosy and Vukov. [PDF]

Linacre Q, 2023
McCarthy A, Watt H.
europepmc   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Comparing Gender Differences in Willingness to Accept Same- and Other-Sex Dyadic and Multi-Person Sexual Offers: An Examination of the Backlash Effect

Behavioral Sciences
Proponents of Sexual Script Theory posit that men and women differ in their sexual behaviors/motivations, often due to culturally ingrained expectations.
Ashley E. Thompson, Lizzy Bensen, Ryan Scoats   +2 more
doaj   +1 more source

Infecundity and the Principle of Double Effect in the Congregation for the Doctrine of the Faith's 2018 Responsum on Hysterectomy. [PDF]

Linacre Q, 2023
Dezort S.
europepmc   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source