Results 81 to 90 of about 1,701,712 (263)
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Double-Effect Donation or Bodily Respect? A "Third Way" Response to Camosy and Vukov. [PDF]
Linacre Q, 2023 McCarthy A, Watt H.
europepmc +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
CATALYTIC PROPERTY OF DOUBLE LAYERED PEROVSKITES A2MM’O6 FOR RADIOLYTICAL SPLIT OF WATER [PDF]
Chemistry Journal of Moldova: General, Industrial and Ecological Chemistry, 2009 This paper deals with a study of water splitting by gamma rays in the presence of some double perovskites A2MM’O6 and also Sr2Fe1-xTa1+xO6. The irradiation is performed using 60Co as a source with 3·104 Ci activity and 8.3 kGy/h dose rate, which ...
Alexandru Cecal +6 more
doaj
Infecundity and the Principle of Double Effect in the Congregation for the Doctrine of the Faith's 2018 Responsum on Hysterectomy. [PDF]
Linacre Q, 2023 Dezort S.
europepmc +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Ambiente ConstruídoA fachada dupla consiste de duas camadas, em geral envidraçadas, colocadas a certa distância, formando uma cavidade intermediária por onde o ar circula. Essas camadas abrangem fenômenos físicos complexos, como a ventilação por efeito chaminé e as trocas ...
Sabrina Andrade Barbosa +3 more
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
The double-edged nature of nicotine: toxicities and therapeutic potentials
Frontiers in PharmacologyNicotine is the primary addictive component of cigarette smoke and is associated with various smoking-related diseases. However, recent research has revealed its broader cognitive-enhancing and anti-inflammatory properties, suggesting its potential ...
Yun Cao +12 more
doaj +1 more source