Results 61 to 70 of about 12,867,784 (306)
The Double-Edged Effects of MLN4924: Rethinking Anti-Cancer Drugs Targeting the Neddylation Pathway
Biomolecules(1) Background: The neddylation pathway assumes a pivotal role in the initiation and progression of cancer. MLN4924, a potent small-molecule inhibitor of the NEDD8-activating enzyme (NAE), effectively intervenes in the early stages of the neddylation ...
Haoming Tang +3 more
doaj +1 more source
Numerical Simulation of Dufour and Soret Effects on Heat and Mass Transfer in Double-diffusive Convection in Methane Hydrate Reservoirs [PDF]
Journal of Applied and Computational MechanicsIn this paper, the behavior of methane-containing fluids in methane hydrate reservoirs is numerically simulated by investigating the transient thermal solute convection with the Dufour and Soret effects.
Yijie Zhuang +3 more
doaj +1 more source
Effect of Cyclooxygenase-2 Inhibitors in Double J Stent Removal under Local Anesthesia
The Annals of African Surgery, 2021 Introduction: Celecoxib is a selective cyclooxygenase-2(COX-2) inhibitor that can reduce the inflammatory process during double J (DJ) stent removal procedure.
Rulianov Rulianov +3 more
doaj +1 more source
Thermally activated charge fluctuations in GaAs double quantum dots [PDF]
, 2014 In this thesis, laterally defined GaAs quantum dots and double quantum dots are investigated by means of real-time charge sensing. A quantum dot charge sensor, adjacent to the investigated double dot system, detects single electron tunneling with ...
Biesinger, Daniel Erich Fridolin
core +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
, 2002 Perkin and Resnik advocate the use of muscle relaxants to prevent the "agony of agonal respiration" arguing that this is compatible with the principle of double effect. The proposed regime will kill patients as certainly as smothering them would.
Kuhse, H.
core +1 more source
Davis double play effect of share pledging.
, 2021 Davis double play effect of share pledging.
Jaime Ortiz (3847525) +2 more
core +1 more source
Species doubling and effective lagrangians [PDF]
Nuclear Physics B - Proceedings Supplements, 1997 Coupling gauge fields to the chiral currents from an effective Lagrangian for pseudoscalar mesons naturally gives rise to a species doubling phenomenon similar to that seen with fermionic fields in lattice gauge theory.
Creutz, M., Tytgat, M.
openaire +3 more sources
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source