Results 51 to 60 of about 12,867,784 (306)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Journal of Contemporary Pharmacy, 2021 Double-layered controlled release microspheres of venlafaxine were prepared using ethyl cellulose (EC) as a wall forming hydrophobic polymer. Usually, it is difficult to control initial sudden release of highly water-soluble drugs.
Liaqat Ali +6 more
doaj +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Jus in bello a operace Irácká svoboda
Obrana a strategie, 2010 War is a constant feature of human affairs and a permanent topic of ethical debates. Moral reasoning about war and peace known as just war theory has its roots in Christian ethics and is connected to positive international law.
Eva DUŘPEKTOVÁ, Zdeněk KŘÍŽ
doaj
A Double Emulsion-Based, Plastic-Glass Hybrid Microfluidic Platform for Protein Crystallization
Micromachines, 2015 This paper reports the design and construction of a plastic-glass hybrid microfluidic platform for performing protein crystallization trials in nanoliter double emulsions.
Deyong Zhu, Xiaohu Zhou, Bo Zheng
doaj +1 more source
Nonresponse Effect in Double Sampling: A Simulation Study [PDF]
The Egyptian Statistical Journal, 1995 We consider estimation of the population total in double sampling for regression in the presence of nonresponse. Two estimators were examined, one allowing for nonresponse and the other based only on respondents'set.
Mohamad Hasan, Z. EL-Beshir
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Evolution of correlated electrons in La3Ni2O7 at ambient pressure: a study of double-counting effect
AAPPS BulletinWe employ cluster extension of dynamical mean-field theory (CDMFT) to systematically investigate the impact of double counting corrections on the correlated electronic structure of La3Ni2O7 under ambient pressure. By adjusting double-counting parameters,
Zhongyi Xie +3 more
doaj +1 more source