Results 71 to 80 of about 12,867,784 (306)
Effectiveness of anonymization in double-blind review [PDF]
Communications of the ACM, 2018 Assessing the effectiveness of anonymization in the review process.
Claire Le Goues +5 more
openaire +4 more sources
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
The Devil's Choice: Re-Thinking Law, Ethics, and Symptom Relief in Palliative Care
, 2006 Health professionals do not always have the luxury of making "right" choices. This article introduces the "devil's choice" as a metaphor to describe medical choices that arise in circumstances where all the available options are both unwanted and ...
Magnusson, Roger S., Schwartz, Robert
core +1 more source
Computer aids and human second reading as interventions in screening mammography: two systematic reviews to compare effects on cancer detection and recall rate [PDF]
, 2008 Background: There are two competing methods for improving the accuracy of a radiologist interpreting screening mammograms: computer aids (CAD) or independent second reading. Methods: Bibliographic databases were searched for clinical trials.
Paul Taylor +3 more
core +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
A Stronger Doctrine of Double Effect
Australasian Journal of Philosophy, 2017 ABSTRACTMany believe that intended harms are more difficult to justify than are harms that result as a foreseen side effect of one's conduct. We describe cases of harming in which the harm is not intended, yet the harmful act nevertheless runs afoul of the intuitive moral constraint that governs intended harms.
Ben Bronner, Simon Goldstein
openaire +3 more sources
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Zhileng xuebao, 2012 A double-effect and double-way thermochemical sorption refrigeration system was set up. In the system, adsorption refrigeration, resorption refrigeration and internal heat recovery technologies were used to improve system performance. The feasibility and
Yu Nan, Wang Ruzhu, Li Tingxian, Xu Lv
doaj
The doctrine of double effect [PDF]
, 2010 • The doctrine of double effect is an exception to the general rule that taking active steps that end life is unlawful.\ud • The essence of the doctrine at common law is intention.\ud • Hastening a patient’s death through palliative care will be lawful ...
White, Benjamin P., Willmott, Lindy
core
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source