Results 31 to 40 of about 1,701,712 (263)
Journal of Contemporary Pharmacy, 2021 Double-layered controlled release microspheres of venlafaxine were prepared using ethyl cellulose (EC) as a wall forming hydrophobic polymer. Usually, it is difficult to control initial sudden release of highly water-soluble drugs.
Liaqat Ali +6 more
doaj +1 more source
On Automating the Doctrine of Double Effect [PDF]
Proceedings of the Twenty-Sixth International Joint Conference on Artificial Intelligence, 2017 The doctrine of double effect (DDE) is a long-studied ethical principle that governs when actions that have both positive and negative effects are to be allowed. The goal in this paper is to automate DDE. We briefly present DDE, and use a first-order modal logic, the deontic cognitive event calculus, as our framework to formalize the doctrine.
Naveen Sundar Govindarajulu +1 more
openaire +2 more sources
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Effect of Cyclooxygenase-2 Inhibitors in Double J Stent Removal under Local Anesthesia
The Annals of African Surgery, 2021 Introduction: Celecoxib is a selective cyclooxygenase-2(COX-2) inhibitor that can reduce the inflammatory process during double J (DJ) stent removal procedure.
Rulianov Rulianov +3 more
doaj +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
A Double Emulsion-Based, Plastic-Glass Hybrid Microfluidic Platform for Protein Crystallization
Micromachines, 2015 This paper reports the design and construction of a plastic-glass hybrid microfluidic platform for performing protein crystallization trials in nanoliter double emulsions.
Deyong Zhu, Xiaohu Zhou, Bo Zheng
doaj +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Numerical Simulation of Dufour and Soret Effects on Heat and Mass Transfer in Double-diffusive Convection in Methane Hydrate Reservoirs [PDF]
Journal of Applied and Computational MechanicsIn this paper, the behavior of methane-containing fluids in methane hydrate reservoirs is numerically simulated by investigating the transient thermal solute convection with the Dufour and Soret effects.
Yijie Zhuang +3 more
doaj +1 more source