Results 41 to 50 of about 12,354,095 (294)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Micromachines, 2022 Due to the influence of nonlinear loads, power quality control devices under the traditional double closed-loop control strategy suffer from a large output voltage harmonic distortion rate and a slow harmonic suppression response and cannot meet the high-
Chengkuan Wan +5 more
doaj +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
F1000Research, 2023 Background Ethical dilemmas can occur in any situation in clinical medicine. In patients undergoing neuro-anesthesia for surgical procedure evacuation of intracerebral hemorrhage with a history of hemorrhagic stroke, anticoagulants should not be given ...
Taufik Suryadi, Kulsum Kulsum
doaj +1 more source
The Principle of Double Effect and Proportionate Reason
AMA Journal of Ethics, 2007 Health care providers can apply the principle of double effect and proportionate reasoning to assess whether or not some medical treatments are morally justifiable. Virtual Mentor is a monthly bioethics journal published by the American Medical Association.
openaire +2 more sources
Artificial molecular machines and motors—Design and control of nanoscale motion
FEBS Letters, EarlyView.Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley +1 more source
Jixie chuandong, 2001 According to the mesh principle of gear, applying double-parameter envelope function, the authors developed the flank equation of gear from double-circular-arc gear hob, and provided a numerical solution which can be used to investigate the effect of ...
邓力, 张廷健, 袁和相, 周军
doaj
Business is not just war. Transferring the principle of double effect from war to business
, 2005 In this article the validity of transferring the Principle of Double Effect from the just war tradition to the domain of business is critically reviewed.
Rossouw, G. J.
core +1 more source
FEBS Letters, EarlyView.Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley +1 more source