Results 91 to 100 of about 2,208,881 (288)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

The research on mining along next goaf technology of double gateways excavation in super-long forward distance working face

矿业科学学报, 2017
With theoretical analysis and field measurement, the research is conducted on mining along next goaf technology of double gateways excavation in super-long forward distance working face.
Wang Zhiqiang, Wang Jianming, Guo Lei, Xu Jie   +3 more
doaj  

Effects of Terpenes on the Osteoarthritis Cytokine Profile by Modulation of IL-6: Double Face versus Dark Knight? [PDF]

Biology (Basel), 2023
Farì G, Megna M, Scacco S, Ranieri M, Raele MV, Noya EC, Macchiarola D, Bianchi FP, Carati D, Gnoni A, Inchingolo AD, Qorri E, Scarano A, Scacco A, Arrigoni R, Rapone B.   +15 more
europepmc   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Pumping pillar technology of fully mechanized caving face passing through abandoned roadway

Gong-kuang zidonghua, 2019
Existing working face passing through abandoned roadway based on traditional support methods cannot adapt to changeable geological conditions well. Based on research background of 8103 fully mechanized caving face of Yongdingzhuang Coal Industry Co., Ltd.
HAO Yuhui, KANG Guanxian
doaj   +1 more source

The Double Face of miR-708: A Pan-Cancer Player with Dissociative Identity Disorder. [PDF]

Genes (Basel), 2022
Carvalho de Oliveira J, Mathias C, Oliveira VC, Pezuk JA, Brassesco MS.   +4 more
europepmc   +1 more source

Fear and the human amygdala [PDF]

, 1995
We have previously reported that bilateral amygdala damage in humans compromises the recognition of fear in facial expressions while leaving intact recognition of face identity (Adolphs et al., 1994).
Adolphs, Ralph, Damasio, Antonio R., Damasio, Hanna, Tranel, Daniel   +3 more
core  

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

分阶式双渐开线齿轮啮合特性及有限元研究

Jixie chuandong, 2008
The design theories of basic rack tooth profile and mathematical model of the double involutes gear are established by using the mesh theory.The formula of the end face and the contact line are also deduced.The mesh process of end face and the change of ...
张光辉, 李凤吉, 魏静
doaj  

Double trouble belowground: grapevine rootstocks face drought and copper toxicity

Frontiers in Agronomy
Background and aimsClimate change is intensifying abiotic stresses in viticulture, particularly through increased drought due to erratic rainfall.
R. Fattorini, T. O. Caretta, F. Benyahia, M. Y. A. Zuluaga, S. Monterisi, A. Agostini, C. Andreotti, S. Cesco, Y. Pii   +8 more
doaj   +1 more source