Results 41 to 50 of about 3,960,683 (297)
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
The double face of the histone variant H3.3 [PDF]
Cell Research, 2011 Histone proteins wrap DNA to form nucleosome particles that compact eukaryotic genomes while still allowing access for cellular processes such as transcription, replication and DNA repair. Histones exist as different variants that have evolved crucial roles in specialized functions in addition to their fundamental role in packaging DNA.
Szenker, Emmanuelle +2 more
openaire +3 more sources
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
On the Double-Faced Nature of P2P Traffic [PDF]
16th Euromicro Conference on Parallel, Distributed and Network-Based Processing (PDP 2008), 2008 Over the last few years, peer-to-peer (P2P) file sharing applications have evolved to become a major traffic source in the Internet. The ability to quantify their impact on the network, as a consequence of both signaling and download traffic, is fundamental to a number of network operations, including traffic engineering, capacity planning, quality of ...
Raffaele Bolla +3 more
openaire +4 more sources
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Research of gas movement law in goaf with parallel double U-shape ventilation mode
Gong-kuang zidonghua, 2014 In order to analyze and master gas distribution and movement law in goaf with parallel double U-shape ventilation mode, a CFD model was established according to characteristics of parallel double U-shape ventilation system of fully mechanized coal mining
HAO Yabing +3 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Orthopedic Treatment of Skeletal Class III Malocclusions With Maxillary Deficiency
Turkish Journal of Orthodontics, 2015 Objective:The purpose of this study was to compare the treatment effects of a double-plate appliance (DPA) and a double-plate appliance and facemask combination (DPA-FM) in correcting Class III malocclusions.Materials and Methods:The material consisted ...
Erdal Bozkaya +5 more
doaj +1 more source
Semina: Ciências Agrárias, 2021 The objective of this study was to evaluate the efficiency of different types of sealing on the physical losses of dry matter, chemical and fermentation characteristics and in situ digestibility of the dry matter of corn silage stored in the feed out ...
Mikael Neumann +8 more
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source