Results 31 to 40 of about 26,398 (263)

Optimal Viscous Damper Placement for Elastic-Plastic MDOF Structures Under Critical Double Impulse

Frontiers in Built Environment, 2019
A new method for optimal viscous damper placement is proposed for elastic-plastic multi-degree-of-freedom (MDOF) structures subjected to the critical double impulse as a representative of near-fault ground motions.
Hiroki Akehashi, Izuru Takewaki
doaj   +1 more source

Closed-form overturning limit of rigid block under critical near-fault ground motions

Frontiers in Built Environment, 2016
A closed-form limit on the input level of the double impulse as a substitute of a near-fault ground motion is derived for the overturning of a rigid block.
Kunihiko eNabeshima, Ryo eTaniguchi, Kotaro eKojima, Izuru eTakewaki   +3 more
doaj   +1 more source

Examining Metal Additives in a Marine Hybrid-Propellant, Water-Breathing Ramjet

Journal of Marine Science and Engineering, 2022
This research focuses on theoretically and experimentally evaluating the performance of a metallized hybrid-propellant, water-breathing ramjet. The aluminum and/or magnesium particles added to a polymeric (polyester) fuel grain are hydro-reactive, using ...
Nachum E. Eisen, Alon Gany
doaj   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Double Perturbations for Impulsive Differential Equations in Banach Spaces

Taiwanese Journal of Mathematics, 2016
In this article, we are concerned with the existence of extremal solutions to the initial value problem of impulsive differential equations in ordered Banach spaces. The existence and uniqueness theorem for the solution of the associated linear impulsive differential equation is established.
Chen, Pengyu, Li, Yongxiang, Zhang, Xuping   +2 more
openaire   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Experimental investigation of cavity dynamics and pressure created by cumulative hydrodynamic ram

Results in Engineering, 2021
The impact of high-velocity projectile on fluid-filled containers can cause hydrodynamic ram (HRAM) events. When multiple projectiles impact, HRAM effect is superimposed.
Yangziyi Ji, Xiangdong Li, Lanwei Zhou, Anran Chen   +3 more
doaj   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source