Results 51 to 60 of about 27,026 (255)

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw   +5 more
wiley   +1 more source

Evidence for double injections in scatter‐free solar impulsive electron events [PDF]

open access: yesGeophysical Research Letters, 2006
We investigate the injection at the Sun for three scatter‐free impulsive electron events (7 August 1999, 28 June and 22 August 2000) observed from ∼0.4 to 300 keV by the WIND 3DP instrument. Taking into account the interplanetary scatter‐free propagation and instrumental effects, we find that the observed time profiles of electron fluxes at all ...
Wang, Linghua   +3 more
openaire   +3 more sources

Interaction of Intraprocedural Antiplatelets and Intravenous Thrombolysis in Acute Intracranial Stenting: RESISTANT Registry Subanalysis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction/Objective Acute intracranial stenting during endovascular thrombectomy (EVT) for ischemic stroke requires intraprocedural antiplatelet therapy (APT) to maintain patency. However, the hemorrhagic risk of combining APT with intravenous thrombolysis (IVT) remains uncertain.
Aaron Rodriguez‐Calienes   +75 more
wiley   +1 more source

Surrogate impulse ground motion for practical simulation of critical nonlinear structural responses

open access: yesFrontiers in Built Environment
Impulse-based representations of earthquake ground motions provide an efficient framework for evaluating critical nonlinear structural responses. However, the direct use of ideal impulse ground motions expressed by Dirac’s delta function may excite all ...
Hiroki Akehashi   +5 more
doaj   +1 more source

Clinical Practice Guideline for Evaluation and Management of Peripheral Nervous System Manifestations in Sjögren's Disease

open access: yesArthritis Care &Research, EarlyView.
Objective Sjögren's disease is an autoimmune disorder that can impact multiple organ systems, including the peripheral nervous system (PNS). PNS manifestations, which can exist concurrently, include mononeuropathies, polyneuropathies, and autonomic nervous system neuropathies.
Anahita Deboo   +88 more
wiley   +1 more source

Review: Critical Excitation Problems for Elastic–Plastic Structures Under Simple Impulse Sequences

open access: yesJapan Architectural Review
This review paper treats critical excitation methods and discusses the possibility of a paradigm shift in nonlinear structural dynamics for building structures with hysteresis using input model transformation without structural model transformation. Long‐
Izuru Takewaki
doaj   +1 more source

Perceived Impacts and Predictors of Cannabis Products Used by Patients with Rheumatologic Conditions in Alberta, Canada: A Multivariable Analysis of Cross‐Sectional Survey Data

open access: yesArthritis Care &Research, EarlyView.
Objective This study aimed to characterize cannabis product choices (cannabinoid content and formulation) among patients with rheumatologic conditions and their associations with patient factors, patient‐reported perceived side effects, and positive impacts.
Susan Zhang   +10 more
wiley   +1 more source

Pengaruh Penempatan Produk di Kasir dan Sales Person terhadap Impulse Buying

open access: yesJournal the Winners, 2011
Product placement in the cashier and using sales person have important effects for impulse purchasing in a retail that will increase company selling. The purpose of this research is to acknowledge product placement influences in cashier and sales person
Dian Tauriana, Ika Fietrin
doaj   +1 more source

Experimental and Numerical Modal Analysis of Composite Sandwich Structures Using Surfboards as Model Systems

open access: yesAdvanced Engineering Materials, EarlyView.
This article presents an experimental and numerical modal investigation of composite sandwich structures using surfboards as model systems. By comparing different core materials and reinforcement strategies, the study demonstrates how local stiffeners influence vibrational response and introduce characteristic modal features, highlighting modal ...
Brett Connellan   +4 more
wiley   +1 more source

Critical Response of Nonlinear Base-Isolated Building Considering Soil-Structure Interaction Under Double Impulse as Substitute for Near-Fault Ground Motion

open access: yesFrontiers in Built Environment, 2018
The critical nonlinear response considering soil-structure interaction is investigated for a base-isolated building under a double impulse as a substitute for near-fault earthquake ground motions.
Hiroki Akehashi   +3 more
doaj   +1 more source

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