Results 31 to 40 of about 1,649,082 (293)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Latest results from Double Chooz

, 2017
Double Chooz is a short-baseline neutrino disappearance experiment. It detects ν̄e produced in the power plant of Chooz, France, where is located. The main goal of the experiment is the measurement of θ13 mixing angle and in 2011 for the first time the ...
Minotti A., Double Chooz collaboration
core   +1 more source

Closed-form overturning limit of rigid block under critical near-fault ground motions

Frontiers in Built Environment, 2016
A closed-form limit on the input level of the double impulse as a substitute of a near-fault ground motion is derived for the overturning of a rigid block.
Kunihiko eNabeshima, Ryo eTaniguchi, Kotaro eKojima, Izuru eTakewaki   +3 more
doaj   +1 more source

Caractérisation expérimentale de plasmas induits par impulsion laser en régime de double impulsion

Journal International de Technologie, de l'Innovation, de la Physique, de l'Energie et de l'Environnement, 2019
La spectroscopie optique d’émission sur plasma induit par laser (LIBS, acronyme de Laser-Induced Breakdown Spectroscopy) est aujourd’hui une puissante méthode d’analyse de composition multi-élémentaire. Ce procédé utilisant  une source laser impulsionnelle permet en effet de déterminer une quantité importante d’informations  relatives au plasma généré ...
Favre, Aurélien, Morel, Vincent, Grisolia, C., Bultel, Arnaud   +3 more
openaire   +3 more sources

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Optimal Viscous Damper Placement for Elastic-Plastic MDOF Structures Under Critical Double Impulse

Frontiers in Built Environment, 2019
A new method for optimal viscous damper placement is proposed for elastic-plastic multi-degree-of-freedom (MDOF) structures subjected to the critical double impulse as a representative of near-fault ground motions.
Hiroki Akehashi, Izuru Takewaki
doaj   +1 more source

Examining Metal Additives in a Marine Hybrid-Propellant, Water-Breathing Ramjet

Journal of Marine Science and Engineering, 2022
This research focuses on theoretically and experimentally evaluating the performance of a metallized hybrid-propellant, water-breathing ramjet. The aluminum and/or magnesium particles added to a polymeric (polyester) fuel grain are hydro-reactive, using ...
Nachum E. Eisen, Alon Gany
doaj   +1 more source

Impulsive Synchronization Between Double-Scroll Circuits

, 2012
Two identical, double-scroll circuits, in their chaotic mode of operation, are unidirectionally connected via an externally triggered electronic switch. Thus, the case of impulsive synchronization is established. Their synchronization and its dependence on the switch on-off frequency and duty cycle is demonstrated.
Volos, Ch. K., Stavrinides, S. G., Kyprianidis, I. M., Stouboulos, I. N., Özer, Mehmet, Anagnostopoulos, A. N.   +5 more
openaire   +2 more sources

Robustness analysis of elastoplastic structure subjected to double impulse [PDF]

Journal of Sound and Vibration, 2016
The double impulse has extensively been used to evaluate the critical response of an elastoplastic structure against a pulse-type input, including near-fault earthquake ground motions. In this paper, we propose a robustness assessment method for elastoplastic single-degree-of-freedom structures subjected to the double impulse input.
Yoshihiro Kanno, Izuru Takewaki
openaire   +2 more sources

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source