Results 61 to 70 of about 30,090 (307)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Controlling double ionization of atoms in an intense bichromatic laser pulse [PDF]

Physical Review E, 2011
We consider the classical dynamics of a two-electron system subjected to an intense bichromatic linearly polarized laser pulse. By varying the parameters of the field, such as the phase lag and the relative amplitude between the two colors of the field, we observe several trends from the statistical analysis of a large ensemble of trajectories ...
Kamor, Adam, Mauger, Francois, Chandre, Cristel, Uzer, Turgay   +3 more
openaire   +4 more sources

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Hot electron electrochemistry at silver activated by femtosecond laser pulses

Opto-Electronic Advances, 2023
A silver microelectrode with a diameter of 30 µm in an aqueous K2SO4 electrolyte was irradiated with 55 fs and 213 fs laser pulses. This caused the emission of electrons which transiently charged the electrochemical double layer.
Oskar Armbruster, Hannes Pöhl, Wolfgang Kautek   +2 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Coherent, Short-Pulse X-ray Generation via Relativistic Flying Mirrors

Quantum Beam Science, 2018
Coherent, Short X-ray pulses are demanded in material science and biology for the study of micro-structures. Currently, large-sized free-electron lasers are used; however, the available beam lines are limited because of the large construction cost.
Masaki Kando, Timur Zh. Esirkepov, James K. Koga, Alexander S. Pirozhkov, Sergei V. Bulanov   +4 more
doaj   +1 more source

Spectral Enhancement in the Double Pulse Regime of Laser Proton Acceleration [PDF]

Physical Review Letters, 2010
The use of two separate ultraintense laser pulses in laser-proton acceleration was compared to the single pulse case employing the same total laser energy. A double pulse profile, with the temporal separation of the pulses varied between 0.75-2.5 ps, was shown to result in an increased maximum proton energy and an increase in conversion efficiency to ...
Markey, K., McKenna, P., Brenner, C. M., Carroll, D. C., Günther, M.M., Harres, K., Kar, S., Lancaster, K., Nürnberg, F., Quinn, M. N., Robinson, A. P. L., Roth, M., Zepf, M., Neely, D.   +13 more
openaire   +5 more sources

Refractive index modification using fs-laser double pulses

, 2022
S.10149-10153Buried waveguides in glass are manufactured by irradiation with femtosecond laser double pulses. The refractive index change Delta n is determined by measuring the numerical aperture NA of the waveguides and by through light microscopy.
Ramme, M., Gottmann, J., Wortmann, D.
core   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Coherence automatic adjustment of the optical pulses inside mode-lock fiber laser cavity [PDF]

, 2018
In the current work we demonstrate mode-locked fiber laser with automatic adjustment a coherence degree of the output pulses. As a source of the pulses we used 8-figure fiber laser with two amplifying fibers inside both loops of the laser cavity.
Alexey Kokhanovskiy, Turitsyn, Sergei K., Aleksey Ivanenko, Kobtsev, Sergey M., Sergey M. Kobtsev, Kokhanovskiy, Alexey, Sergey Turitsyn, Ivanenko, Aleksey   +7 more
core   +1 more source