Results 91 to 100 of about 79,920 (305)
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Administrative SciencesPurpose: The new global approach to sustainability within the context of the SDGs is driving a digital transition. However, new technologies bring challenges related to the energy efficiency of their infrastructures.
Manuela Sánchez-Vázquez +3 more
doaj +1 more source
ESG Management Strategy Analysis for Biodiversity Activity Intergrity: The Case of POSCO Group [PDF]
대한환경공학회지Objectives In this study, we analyzed the corporation’s current status and issues related to biodiversity and provided insights based on the results for future consideration.
Chaehyeon Kim +3 more
doaj +1 more source
Library As Place: Being Human in a Digital World
, 2014 Despite the increasingly digital nature of information retrieval, both users and computers continue to occupy physical space, and the library – as place – offers an essential location for inspiration.
Clark, Amanda C.R.
core +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Layered double hydroxide/sepiolite heterostructured materials
Applied Clay Science, 2016 Oral presentation given at the Euroclay 2015, held in Edinburgh (Scotland), on July 5-10th, 2015.
Gómez Avilés, Almudena +2 more
openaire +3 more sources
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Is copyright blind to the visual? [PDF]
, 2008 This article argues that, with respect to the copyright protection of works of visual art, the general uneasiness that has always pervaded the relationship between copyright law and concepts of creativity produces three anomalous results. One of these is
Armstrong, E. +26 more
core +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Historia Crítica, 2010 This article examines the way that Uruguayan author Mauricio Rosencof reconstructs family genealogy and self identity in Las cartas que no llegaron.
Anna Forné.
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