Results 91 to 100 of about 10,952,065 (350)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Real effects of greenhouse gas disclosures

China Journal of Accounting Research
This study investigates the valuation and real effects of the mandatory disclosure of greenhouse gas (GHG) emission costs from the perspective of “double materiality.” We consider a firm with a Cobb-Douglas production function that combines GHG-related ...
Tong Lu, Lijun Ruan, Yanyan Wang, Lisheng Yu   +3 more
doaj   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

The production of maquiladora space in Motul, Mexico: from henequen municipality to industrial city

Articulo: Journal of Urban Research, 2020
At the intersection of commodity chains and urban research, this paper engages with Bair and Werner’s “disarticulations perspective” through a conversation with Lefebvre’s “production of space.” I argue that this mix can provide a stronger theoretical ...
Claudia Fonseca Alfaro
doaj   +1 more source

Language, Subjectivity and Individuality [PDF]

, 2007
It is clear that within Deleuze and Whitehead’s work, there is an important re- description of the time, place and status of all subjectivity, a subjectivity which is not limited to the ‘human’. Both writers provide compelling reasons as to why, and how,
Halewood, Michael
core   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Is copyright blind to the visual? [PDF]

, 2008
This article argues that, with respect to the copyright protection of works of visual art, the general uneasiness that has always pervaded the relationship between copyright law and concepts of creativity produces three anomalous results. One of these is
Armstrong, E., Bently, L., Blakeney, M., Bloom, H., Boggs, J.S.C., Bonnett, A., Bowrey, K., Chilvers, I., Eco, U., Fiona Macmillan, Julius, A., Kant, I., Landau, D., Landes, W., Macmillan Patfield, F., Panofsky, E., Pon, L., Rosand, D., Sherman, B., Stapleton, J., Sterling, J.A.L., Stokes, S., Teilmann, S., Vaidhyanathan, S., Van Caenegem, W., Waldron, J., Wilson, A.   +26 more
core   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Valuing service design: Lessons from SROI [PDF]

, 2012
This paper describes lessons learned through the use of a Social Return On Investment (SROI) approach to evaluate a completed Service Design project with a large vocational training company.
Lievesley, Matthew, Yee, Joyce
core