Results 91 to 100 of about 1,857 (290)
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
10 Double Bind: On Material Ethics
, 2021 The chapter champions the neologism ethico-aesthetic in order to underline the inseparability of action and perception. The chapter argues that it is practice and experimentation that actively shape the subject. Until recently the sentient was considered as a mere supplement to the sapient.
openaire +2 more sources
Administrative SciencesPurpose: The new global approach to sustainability within the context of the SDGs is driving a digital transition. However, new technologies bring challenges related to the energy efficiency of their infrastructures.
Manuela Sánchez-Vázquez +3 more
doaj +1 more source
ESG Management Strategy Analysis for Biodiversity Activity Intergrity: The Case of POSCO Group [PDF]
대한환경공학회지Objectives In this study, we analyzed the corporation’s current status and issues related to biodiversity and provided insights based on the results for future consideration.
Chaehyeon Kim +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Integrating Double Materiality : As Simple As Ticking a Box
Regulatory frameworks for sustainability reporting have become increasingly more prevalent within the EU, with the latest being CSRD. CSRD requires companies to report both impact and financial materiality, a considerable change from preceding ones.
Lindberg, Ronja, Fälth, Lisa
core +1 more source
Reporting for change: does the adoption of double materiality influence ESG risk management?
Purpose – Drawing on the theoretical distinction between substantive and symbolic sustainability reporting, this study examines whether the adoption of double materiality in sustainability reporting influences ESG risk management.
Silvia Panfilo +2 more
core +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
A blueprint for double materiality assessment [PDF]
This thesis presents a comprehensive framework for implementing Double Materiality Assessment (DMA) in corporate sustainability reporting, in alignment with the European Union's Corporate Sustainability Reporting Directive (CSRD).
Karimov, Elmar
core