Results 101 to 110 of about 213,326 (261)
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Invariant summability and invariant statistical convergence of order η for double set sequences
, 2021 In this study, for double set sequences, we introduce the notions of invariant summability and invariant statistical convergence of order η (0 < η ≤ 1) in the Wijsman sense. Also, we investigate some properties of these new notions and the relations between them.
Ulusu, Uğur, Nuray, Fatih
openaire +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Lacunary ideal convergence of double set sequences
, 2015 [Abstract Not Available]
openaire +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Asymptotically I2-Ces`aro equivalence of double sequences of sets
, 2016 In this paper, we defined concept of asymptotically I_2-Ces`aro equivalence and investigate the relationships between the concepts of asymptotically strongly I_2-Ces`aro equivalence, asymptotically strongly I_2-lacunary equivalence, asymptotically p-strongly I_2-Ces`aro equivalence and asymptotically I_2-statistical equivalence of double sequences of ...
Ulusu, Uğur +2 more
openaire +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Asymptotically I_2-lacunary statistical equivalence of double sequences of sets
, 2015 In this paper, we introduce the concepts of Wijsman asymptotically I_2-statistical equivalence, Wijsman strongly asymptotically I_2-lacunary equivalence and Wijsman asymptotically I_2-lacunary statistical equivalence of double sequences of sets and investigate the relationship between ...
Ulusu, Uğur, Dündar, Erdinç
openaire +2 more sources
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source