Results 101 to 110 of about 965,807 (276)
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Generating information-dense promoter sequences with optimal string packing.
PLoS Computational BiologyDense arrangements of binding sites within nucleotide sequences can collectively influence downstream transcription rates or initiate biomolecular interactions.
Virgile Andreani +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Occurrence of Thermotolerant Hartmannella Vermiformis and Naegleria Spp. in Hot Springs of Ardebil Province, Northwest Iran [PDF]
Iranian Journal of Parasitology, 2012 Background: Geothermal waters could be suitable niches for thermophilic free living amoebae including Naegleria and Hartmannella. Ardebil Province, northwest Iran is popular for having many hot springs for recreational and health purposes activity.
E Nazemalhosseini Mojarad +3 more
doaj +2 more sources
Facial Expression Recognition From Image Sequence Based on LBP and Taylor Expansion
IEEE Access, 2017 The aim of an automatic video-based facial expression recognition system is to detect and classify human facial expressions from image sequence. An integrated automatic system often involves two components: 1) peak expression frame detection and 2 ...
Yuanyuan Ding +3 more
doaj +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
IEEE AccessThe high-intensity electric fields, which are in the vicinity of power transmission lines, have adverse effects on human and other living beings if they are not within the specified limits.
Tesfaye Nafo Tefera +3 more
doaj +1 more source
Invariant and invariant statistical equivalence of order β for double set sequences
, 2021 In this paper, for double set sequences, the concepts of asymptotical invariant equivalence and asymptotical invariant statistical equivalence of order β (0 < β ≤ 1) in the Wijsman sense were introduced. Also, some properties of these new equivalence concepts and the relations between them were investigated.
Gülle, Esra, Ulusu, Uğur
openaire +1 more source