Doublesex: a conserved downstream gene controlled by diverse upstream regulators
Journal of Genetics, 2010 Sex determination, an integral precursor to sexual reproduction, is required to generate morphologically distinct sexes. The molecular components of sex-determination pathways regulating sexual differentiation have been identified and characterized in ...
J. Nagaraju +3 more
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DMRT Transcription Factors in the Control of Nervous System Sexual Differentiation
Frontiers in Neuroanatomy, 2022 Sexual phenotypic differences in the nervous system are one of the most prevalent features across the animal kingdom. The molecular mechanisms responsible for sexual dimorphism throughout metazoan nervous systems are extremely diverse, ranging from ...
Rafael Casado-Navarro +1 more
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Doublesex homolog is sex-specifically spliced and governs the sexual differentiation process in the whitefly Bemisia tabaci AsiaII-1 [PDF]
, 2022 The silverleaf whitefly Bemisia tabaci is one of the most destructive of crop pests globally. In Northern India cotton is predominately infested by the Asia II-1 species of B. tabaci. Though B.
Singh, S. +7 more
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The ubiquity and ancestry of insect doublesex [PDF]
Scientific Reports, 2015 AbstractThe doublesex (dsx) gene functions as a molecular switch at the base of the insect sex determination cascade and triggers male or female somatic sexual differentiation in Drosophila. Having been reported from only seven current insect orders, the exact phylogenetic distribution of dsx within the largest Arthropod sub-phylum, the Hexapoda, is ...
Dana C. Price +2 more
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Transgenic and knockout analyses of Masculinizer and doublesex illuminated the unique functions of doublesex in germ cell sexual development of the silkworm, Bombyx mori [PDF]
BMC Developmental Biology, 2020 Abstract Background: Masculinizer (Masc) plays a pivotal role in male sex determination in the silkworm, Bombyx mori. Masc is required for male-specific splicing of B. mori doublesex (Bmdsx) transcripts. The male isoform of Bmdsx (BmdsxM) induces male differentiation in somatic cells, while females express the female isoform of Bmdsx (BmdsxF ...
Yuzawa, Tomohisa +5 more
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Flipping the doublesex switch with a piRNA [PDF]
Genome Biology, 2014 Recent work in the silkworm Bombyx mori has uncovered a novel Piwi-interacting RNA regulator of the sex determination switch doublesex.
Whitworth, Cale, Oliver, Brian
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Prokaryotic Expression of Doublesex Gene From Macrobrachium rosenbergii and Protein Purification
Guangdong nongye kexue, 2023 【Objective】Doublesex, a member of the DMRT gene family, plays a key role in controlling sex-specific differentiation. To clone the Open Reading Frame (ORF) of Macrobrachium rosenbergii Doublesex (MrDsx) gene, construct the recombinant plasmid and induce ...
Ruirui WANG, Keyi MA
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Constraints on the evolution of adoublesextarget gene arising from doublesex’s pleiotropic deployment [PDF]
Proceedings of the National Academy of Sciences, 2015 SignificanceMost sexually dimorphic features ofDrosophila melanogasterare specified by the action of sex-specific transcription factors encoded by thedoublesex(dsx) gene. Evolutionary changes in such sexually dimorphic features are often a result of changes in thecis-regulatory sequences of the DSX target genes.
Shengzhan D, Luo, Bruce S, Baker
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Molecular and cellular origins of behavioral sex differences: a tiny little fly tells a lot
Frontiers in Molecular Neuroscience, 2023 Behavioral sex differences primarily derive from the sexually dimorphic organization of neural circuits that direct the behavior. In Drosophila melanogaster, the sex-determination genes fruitless (fru) and doublesex (dsx) play pivotal roles in producing ...
Kosei Sato, Daisuke Yamamoto
doaj +1 more source
Courtship Love Songs: doublesex Makes the Connection [PDF]
Developmental Cell, 2016 During courtship, Drosophila melanogaster males sing to females a song composed of rhythmic pulses and sine song. In this issue of Developmental Cell, Shirangi et al. (2016) show that a cluster of doublesex-expressing neurons directs the production of the sine song component through functional linkages to wing motoneurons.
Michelle N, Arbeitman, Nicole R, Newell
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