Experimental and modeling demonstration of stronger population suppression by gene drive targeting doublesex from dominant female-sterile resistance alleles [PDF]
Nature CommunicationsCRISPR homing drives can be used to suppress a population by targeting female fertility genes. They convert wild-type alleles to drive alleles in the germline of drive heterozygotes, but resistance alleles can weaken suppressive power, or even stop ...
Weizhe Chen, Ziye Wang, Jackson Champer
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A conserved family of doublesex-related genes from fishes
Journal of Experimental Zoology, 2002 The sex-determining gene Mab-3 of C. elegans and the doublesex gene of Drosophila each contain a common DM domain and share a similar role. Human doublesex-related gene DMRT1 also encodes a conserved DM-related DNA-binding domain.
LI LIU +5 more
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Sexually dimorphic traits in the silkworm, Bombyx mori, are regulated by doublesex [PDF]
Insect Biochemistry and Molecular Biology, 2017 The DM domain genes, doublesex (dsx) in insects, or their structural homologs, male abnormal 3 (mab-3) in nematodes and Dmrt1 (doublesex and mab-3-related transcription factor 1) in mammals, are downstream regulators of the sex determination pathway that
Tan, Anjiang +15 more
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Tissue-specific metabolomic signatures for a doublesex model of reduced sexual dimorphism [PDF]
Royal Society Open ScienceSex has a major effect on the metabolome. However, we do not yet understand the degree to which differences in metabolism are associated with anatomical dimorphism and modulated by sex-specific tissues. In the fruit fly, Drosophila melanogaster, knocking
Rene Coig +4 more
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Establishing a dominant early larval sex-selection strain in the Asian malaria vector Anopheles stephensi [PDF]
Infectious Diseases of PovertyBackground Genetic biocontrol interventions targeting mosquito-borne diseases require the release of male mosquitoes exclusively, as only females consume blood and transmit pathogens.
Shih-Che Weng +6 more
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Molecular mechanisms of sex determination in Lepidoptera: current status and perspectives. [PDF]
Insect SciThe genetic basis of sex determination in Lepidoptera was discovered in 2014 in the silkworm Bombyx mori. In this model species, the W chromosome‐derived small piRNA called Fem piRNA downregulates the expression of a Z‐linked gene, Masculinizer (Masc), which leads to the default female‐specific splicing of the doublesex gene (dsxF) and thus to female ...
Marec F, Yoshido A, van T Hof AE.
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Feminizer and doublesex knock-outs cause honey bees to switch sexes.
PLoS Biology, 2019 Honey bees are experts at refuting societal norms. Their matriarchal hives are headed by queens, backed by an all-female workforce, and males die soon after copulation.
Alison McAfee +3 more
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Characterization of doublesex and nanos genes in Acropora millepora [PDF]
, 2005 Scleractinian coral, Acropora millepora is a hermaphroditic species which develops both male and female gonads in each polyp at the same time. Corals are diploblastic metazoa and have a simple body structure without well-defined organs. They lack typical
Go, Hiroki
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Developmental link between sex and nutrition; doublesex regulates sex-specific mandible growth via juvenile hormone signaling in stag beetles. [PDF]
PLoS Genetics, 2014 Sexual dimorphisms in trait expression are widespread among animals and are especially pronounced in ornaments and weapons of sexual selection, which can attain exaggerated sizes.
Hiroki Gotoh +7 more
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Effect of the gene doublesex of anastrepha on the somatic sexual development of Drosophila.
PLoS ONE, 2009 BackgroundThe gene doublesex (dsx) is at the bottom of the sex determination genetic cascade and is transcribed in both sexes, but gives rise to two different proteins, DsxF and DsxM, which impose female and male sexual development respectively via the ...
Mercedes Alvarez +2 more
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