Doublesex and GATAβ4 synergistically regulate the sex-dimorphic expression of storage protein 1 in Bombyx mori. [PDF]
PLoS GeneticsSexually dimorphic traits are widespread in organisms and are crucial for reproduction and behavior. These traits are typically controlled by sex-specific genes. However, their regulatory mechanisms are complex and incompletely understood. In Bombyx mori,
Jiamin Yan +7 more
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Genomic analyses revealed low genetic variation in the intron-exon boundary of the doublesex gene within the natural populations of An. gambiae s.l. in Burkina Faso [PDF]
BMC GenomicsBackground The recent success of a population control gene drive targeting the doublesex gene in Anopheles gambiae paved the way for developing self-sustaining and self-limiting genetic control strategies targeting the sex determination pathway to reduce
Mahamadi Kientega +11 more
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Experimental and modeling demonstration of stronger population suppression by gene drive targeting doublesex from dominant female-sterile resistance alleles [PDF]
Nature CommunicationsCRISPR homing drives can be used to suppress a population by targeting female fertility genes. They convert wild-type alleles to drive alleles in the germline of drive heterozygotes, but resistance alleles can weaken suppressive power, or even stop ...
Weizhe Chen, Ziye Wang, Jackson Champer
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Tissue-specific metabolomic signatures for a doublesex model of reduced sexual dimorphism [PDF]
Royal Society Open ScienceSex has a major effect on the metabolome. However, we do not yet understand the degree to which differences in metabolism are associated with anatomical dimorphism and modulated by sex-specific tissues. In the fruit fly, Drosophila melanogaster, knocking
Rene Coig +4 more
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Establishing a dominant early larval sex-selection strain in the Asian malaria vector Anopheles stephensi [PDF]
Infectious Diseases of PovertyBackground Genetic biocontrol interventions targeting mosquito-borne diseases require the release of male mosquitoes exclusively, as only females consume blood and transmit pathogens.
Shih-Che Weng +6 more
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The Masc–PSI complex directly induces male-type doublesex splicing in silkworms [PDF]
Communications BiologyThe WZ sex determination system is found in a diverse range of animals, including lepidopteran insects. In the silkworm Bombyx mori, the masculinizing protein Masculinizer (BmMasc) induces the production of the male-type Bombyx mori doublesex (Bmdsx M ),
Tatsunori Kaneda +7 more
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DMRT Transcription Factors in the Control of Nervous System Sexual Differentiation
Frontiers in Neuroanatomy, 2022 Sexual phenotypic differences in the nervous system are one of the most prevalent features across the animal kingdom. The molecular mechanisms responsible for sexual dimorphism throughout metazoan nervous systems are extremely diverse, ranging from ...
Rafael Casado-Navarro +1 more
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Prokaryotic Expression of Doublesex Gene From Macrobrachium rosenbergii and Protein Purification
Guangdong nongye kexue, 2023 【Objective】Doublesex, a member of the DMRT gene family, plays a key role in controlling sex-specific differentiation. To clone the Open Reading Frame (ORF) of Macrobrachium rosenbergii Doublesex (MrDsx) gene, construct the recombinant plasmid and induce ...
Ruirui WANG, Keyi MA
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Molecular and cellular origins of behavioral sex differences: a tiny little fly tells a lot
Frontiers in Molecular Neuroscience, 2023 Behavioral sex differences primarily derive from the sexually dimorphic organization of neural circuits that direct the behavior. In Drosophila melanogaster, the sex-determination genes fruitless (fru) and doublesex (dsx) play pivotal roles in producing ...
Kosei Sato, Daisuke Yamamoto
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eLife, 2020 Inter-male aggressive behavior is a prominent sexually dimorphic behavior. Neural circuits that underlie aggressive behavior are therefore likely under the control of sex-determining genes.
Margot Wohl +2 more
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