Results 141 to 150 of about 4,698,937 (316)

Infecciones respiratorias en niños con síndrome de Down [PDF]

, 2014
Los problemas respiratorios son causa importante de morbilidad y mortalidad en los niños con síndrome de Down. Recientemente han aparecido en la literatura mundial cinco artículos que abordan aspectos distintos de las infecciones respiratorias en niños ...
Flórez, Jesús
core  

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Mi vida [PDF]

, 2012
Miriam relata de forma conmovedora algunos aspectos de su vida con síndrome de Down como sus dificultades, sus logros, sus valores o sus proyectos de ...
Flórez, Miriam
core  

Type 1 interferons and Foxo1 down-regulation play a key role in age-related T-cell exhaustion in mice

Nature Communications
Foxo family transcription factors are critically involved in multiple processes, such as metabolism, quiescence, cell survival and cell differentiation.
Aurélie Durand, Nelly Bonilla, Théo Level, Zoé Ginestet, Amélie Lombès, Vincent Guichard, Mathieu Germain, Sébastien Jacques, Franck Letourneur, Marcio Do Cruzeiro, Carmen Marchiol, Gilles Renault, Morgane Le Gall, Céline Charvet, Agnès Le Bon, Bruno Martin, Cédric Auffray, Bruno Lucas   +17 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

The role of nitric oxide generation in interferon-evoked cytochrome P450 down-regulation

, 1995
The down-regulation of cytochrome P450 during host defence involves one or more mediators of unknown source and identity. Owing to striking similarities in the features that are involved in the production of NO and the features involved in the down ...
KW Renton (17914361), Peter Hodgson (13089276)   +1 more
core  

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Down-regulation of wheat Rubisco activase isoforms expression by virus-induced gene silencing [PDF]

Rubisco activase (Rca) is an essential photosynthetic enzyme that removes inhibitors from the catalytic sites of the carboxylating enzyme Rubisco. In wheat, Rca is composed of one longer 46 kDa α-isoform and two shorter 42 kDa β-isoforms encoded by the ...
Scales, Joanna, Carmo-Silva, Elizabete, Lee, W., Perdomo Lopez, Alejandro, Kanyuka, K., Scales, J. C., Lee, Wing-Sham, Perdomo, J. A., Kanyuka, Kostya, Carmo-Silva, E.   +9 more
core   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source