Results 121 to 130 of about 4,698,937 (316)
Down‐regulation of TROP‐2 Predicts Poor Prognosis of Hepatocellular Carcinoma Patients
Hepatology Communications, 2018 Hepatocellular carcinoma (HCC) is one of the most common and lethal cancer types worldwide, especially in Asian countries. Genetic alterations, including hyperactivation of oncogenes and loss of expression of tumor suppressor genes, greatly contribute to
Sarah T. K. Sin +5 more
doaj +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
La salud en las personas con Síndrome de Down [PDF]
, 2012 El programa de salud de Down España tiene como objetivos: mejorar la atención sanitaria a las personas con SD, proporcionar una herramienta a los profesionales para llevar a cabo esa función y servir de guía a las familias y a las mismas personas con SD ...
Borrel Martínez, José María
core
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Down-Regulation of a Male-Specific H3K4 Demethylase, KDM5D, Impairs Cardiomyocyte Differentiation
, 2019 Despite the small number of Y chromosome genes, their adequate expression is required for regulation of transcription, translation, and protein stability in males, not just for sex determination.
Sara Pahlavan (4432414) +4 more
core +2 more sources
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
La Convención Internacional de Naciones Unidas sobre los Derechos de las Personas con Discapacidad vista por sus protagonistas [PDF]
, 2012 La Convención Internacional de los Derechos de las Personas con Discapacidad, analizada por sus protagonistas En 2006, representantes de los Gobiernos y la sociedad civil se unieron para debatir, consensuar y redactar una Convención Internacional de los
Down España
core
Roquin Modulates Cardiac Post-Infarct Remodeling via microRNA Stability Control
CellsThrough binding to complementary mRNAs, microRNAs (miRNAs) mediate gene silencing. The stability and half-life of microRNAs are controlled by two isoforms of the RNA-binding protein Roquin.
Nadja Itani +5 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Jurnal Psikologi Teori dan TerapanBackground: Down Syndrome is a genetic disorder that often affects emotional regulation in individuals. Children with down syndrome usually have difficulty understanding and expressing their emotions appropriately.
Sunita Rahayu Putri +4 more
doaj +1 more source