Results 41 to 50 of about 1,209,458 (341)

CTLA-4 and PD-1 ligand gene expression in epithelial thyroid cancers [PDF]

, 2018
The dysregulation of PD-1 ligands (PD-L1 and PD-L2) and CTLA-4 ligands (CD80 and CD86) represents a tumor strategy to escape the immune surveillance. Here, the expression of PD-L1, PD-L2, CD80 and CD86 was evaluated at mRNA level in 94 patients affected ...
Antonelli, Alessandro, Arcieri, Stefano, Baldini, Enke, Barollo, Susi, Carbotta, Giovanni, Catania, Antonio, Fallahi, Poupak, Mian, Caterina, Monti, Massimo, Palmieri, Andrea, Pironi, Daniele, Sorrenti, Salvatore, Tartaglia, Francesco, Tuccilli, Chiara, Ulisse, Salvatore, Vergine, Massimo   +15 more
core   +3 more sources

Phage-induced efflux down-regulation boosts antibiotic efficacy. [PDF]

PLoS Pathog
The interactions between a virus and its host vary in space and time and are affected by the presence of molecules that alter the physiology of either the host or the virus.
Kraus S, Fletcher ML, Łapińska U, Chawla K, Baker E, Attrill EL, O'Neill P, Farbos A, Jeffries A, Galyov EE, Korbsrisate S, Barnes KB, Harding SV, Tsaneva-Atanasova K, Blaskovich MAT, Pagliara S.   +15 more
europepmc   +2 more sources

Mboat7 down-regulation by hyper-insulinemia induces fat accumulation in hepatocytes [PDF]

, 2020
BACKGROUND: Naturally occurring variation in Membrane-bound O-acyltransferase domain-containing 7 (MBOAT7), encoding for an enzyme involved in phosphatidylinositol acyl-chain remodelling, has been associated with fatty liver and hepatic disorders.
Davidson, Nicholas O, et al,, Meroni, Marica   +2 more
core   +1 more source

Research on Down-Regulation Cost of Flexible Combined Heat Power Plants Participating in Real-Time Deep Down-Regulation Market

Energies, 2020
The issue of real-time deep down-regulation ancillary service has received increasing attention in the Northeast of China. Participation of combined heat and power plants with multitype units and flexible heating devices in the market is investigated ...
Yan Zhang, Quan Lyu, Yang Li, Na Zhang, Lijun Zheng, Haoyan Gong, Hui Sun   +6 more
doaj   +1 more source

Short photoperiod-induced decrease of histamine H3 receptors facilitates activation of hypothalamic neurons in the Siberian Hamster [PDF]

, 2009
Nonhibernating seasonal mammals have adapted to temporal changes in food availability through behavioral and physiological mechanisms to store food and energy during times of predictable plenty and conserve energy during predicted shortage.
Bamshad, Barrett, Barrett, Brown, C. K. Song, D. Spanswick, D. Wilson, Doi, Enriori, Franklin, Franklin, Garcia, Gottsch, Inagaki, J. G. Mercer, Jamali, Jamali, Leurs, Liu, M. van den Top, Malmlöf, Morgan, Morgan, Morton, Nakamura, Nilaweera, Ookuma, P. Barrett, P. J. Morgan, Panula, Pillot, Prendergast, Revel, Ross, Sakata, Sallmen, Sallmen, Schneider, Song, Spanswick, Spanswick, T. J. Bartness, Top, Tups, Viguié, Yoshimoto, Yoshimura   +46 more
core   +1 more source

Systematic Survey of the Role of IGF in the Link Between Diabetes and Cancer [PDF]

, 2018
Epidemiological studies have proposed a link between type II diabetes and cancer via the IGF/insulin signaling pathway, which includes insulin-like peptides (IGF1, IGF2, and insulin), insulin receptors (IR-A, IR-B, IGF1R, and hybrids), and insulin ...
Devanathan, Nirupama, Kimble-Hill, Ann C.   +1 more
core   +1 more source

Dampening of proteomics activity associated with the COVID-19 patients afflicted with asthma based on gene expression pattern

Журнал микробиологии, эпидемиологии и иммунобиологии
Introduction. It is established that the severity of SARS-CoV-2 infections varies between individuals without underlying health conditions and those with chronic illnesses like asthma.
Ali Adel Dawood
doaj   +1 more source

Basophil FcεRI Expression in Chronic Spontaneous Urticaria: A Potential Immunological Predictor of Response to Omalizumab Therapy

Acta Dermato-Venereologica, 2017
Although the efficacy of omalizumab has been clearly demonstrated in the treatment of chronic spontaneous urticaria (CSU), its mechanism of action, which results in improvement in CSU symptoms, is not entirely understood. This study investigated
Gustavo Deza, Marta Bertolín-Colilla, Ramon M. Pujol, Laia Curto-Barredo, Dulce Soto, Maribel García, Pilar Hernández, Ramon Gimeno, Ana M. Giménez-Arnau   +8 more
doaj   +1 more source

IRE1α deficiency promotes tumor cell death and eIF2α degradation through PERK dipendent autophagy [PDF]

, 2018
Sensors of endoplasmic reticulum (ER) stress function in a co-ordinated manner. In the present study we investigated the relationship between IRE1α and PERK pathways and survival of ER stressed U937 cells and BC3 cells. To this end, we investigated the
Alfano, Vincenzo, Carbotta, Sabino, Di Renzo, Livia, Ferretti, Elisabetta, Storniolo, Antonello   +4 more
core   +2 more sources

Down-regulation of ROBO2 Expression in Prostate Cancers [PDF]

Pathology & Oncology Research, 2013
Several lines of evidence exist that axon guidance genes are involved in cancer pathogenesis. Axon guidance genes ROBO1 and ROBO2 are candidate tumor suppressor genes (TSG). The aim of our study was to address whether ROBO1 and ROBO2 expressions are altered in prostate cancers (PCA).
Nam Jin Yoo, Sug Hyung Lee, Youn Jin Choi   +2 more
openaire   +3 more sources