Results 101 to 110 of about 1,226,398 (302)

Evidence of blood–brain barrier dysfunction and CSF immunoglobulin synthesis in Down Syndrome Regression Disorder

Annals of Clinical and Translational Neurology
Objectives This study sought to evaluate proteomic, metabolomic, and immune signatures in the cerebrospinal fluid of individuals with Down Syndrome Regression Disorder (DSRD). Methods A prospective case–control study comparing proteomic, metabolomic, and
Jonathan D. Santoro, Neetha Paul Eduthan, Mellad M. Khoshnood, Saba Jafarpour, Natalie K. Boyd, Benjamin N. Vogel, Lina Nguyen, Lilia Kazerooni, Eleanor Britton, Hannah R. Lyford, Matthew D. Galbraith, Angela L. Rachubinski, Joaquin M. Espinosa   +12 more
doaj   +1 more source

Humoral Immunity in Children with Down Syndrome [PDF]

, 2015
__Abstract__ Down syndrome is the most common cause of developmental delay in humans. In The Netherlands, each year approximately 250 children with Down syndrome are born.
Verstegen, R.H.J. (Ruud)
core  

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Voxel‐based dysconnectomic brain morphometry with computed tomography in Down syndrome

Annals of Clinical and Translational Neurology
Objective Alzheimer's disease (AD) is a major health concern for aging adults with Down syndrome (DS), but conventional diagnostic techniques are less reliable in those with severe baseline disability.
Beatriz Sánchez‐Moreno, Linda Zhang, Gloria Mateo, Fernando Moldenhauer, Mikael Brudfors, John Ashburner, Parashkev Nachev, Diego Real deAsúa, Bryan A. Strange   +8 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Penatalaksanaan Terapi Latihan Pada Kondisi Down Syndrome Di Ypac Surakarta [PDF]

, 2014
Latar Belakang: Karya tulis ilmiah penatalaksanaan terapi latihan pada kondisi down syndrome ini dimaksudkan untuk memberikan informasi, pengetahuan, dan pemahaman tentang kondisi down syndrome yang menyebabkan timbulnya berbagai permasalahan fisik ...
, Isnaini Herawati, S.Fis., M.Sc,, Ulhaq, Syuja   +1 more
core  

Changing Student Teachers' Attitudes Towards Disability and Inclusion [PDF]

, 2003
A total of 274 preservice teacher education students were surveyed at the beginning and end of a one-semester unit on Human Development and Education which combined formal instruction with structured fieldwork experiences.
Campbell, Karyl, Cuskelly, Monica, Gilmore, Linda   +2 more
core   +2 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

EFEKTIVITAS PENGGUNAAN MEDIA STEMPEL KENTANG PADA PEMBELAJARAN MENGENAL WARNA DALAM MENINGKATKAN KEMAMPUAN KONSENTRASI ANAK DOWN SYNDROME DI SLB NEGERI BUDI UTAMA KOTA CIREBON [PDF]

, 2015
Down syndrome adalah suatu kondisi keterbelakangan perkembangan fisik dan mental anak yang diakibatkan adanya abnormalitas perkembangan kromosom. Abnormalitas kromosom tersebut menyebabkan anak dengan kondisi Down Syndrome memiliki ciri-ciri fisik yang ...
Sholeha, Diana Djawdjatus
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Daily transcutaneous electrical nerve stimulation at home in a patient with Down syndrome [PDF]

, 2015
C
De Bruyne, Ruth, Renson, Catherine, Van Biervliet, Stephanie, Van Winckel, Myriam, Vande Velde, Saskia   +4 more
core   +2 more sources