Results 91 to 100 of about 3,268,379 (302)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Does the well-being of individuals with Down syndrome and dementia improve when using life story books and rummage boxes? A randomised single case series experiment [PDF]

, 2015
Background: This study investigated whether a personalised life story book and rummage box enhanced well-being and led to changes in behaviour for people with Down syndrome (DS) who have dementia. Materials & Methods: A randomised single-case series
Langdon, Peter E., Crook, Nicola, Langdon, Peter E.; id_orcid, Adams, M., Shorten, Nicola, Crook, N., Shorten, N., Adams, Malcolm   +7 more
core   +1 more source

University Students' Attitudes Towards Individuals with Disabilities and Their Education in Türkiye: The Case of a Private Non-Profit University

International Journal of Turkish Education Sciences
The readiness levels of the university environment play a crucial role in enabling individuals with disabilities to benefit more from higher education.
Özlem Özaydın, Yunus Emre Aydın, Döne Kaplan, Gülhan Kalmuk, Mehmet Emin Mansurgüler   +4 more
doaj   +1 more source

The importance of understanding individual differences in Down syndrome [version 1; referees: 2 approved]

F1000Research, 2016
In this article, we first present a summary of the general assumptions about Down syndrome (DS) still to be found in the literature. We go on to show how new research has modified these assumptions, pointing to a wide range of individual differences at ...
Annette Karmiloff-Smith, Tamara Al-Janabi, Hana D'Souza, Jurgen Groet, Esha Massand, Kin Mok, Carla Startin, Elizabeth Fisher, John Hardy, Dean Nizetic, Victor Tybulewicz, Andre Strydom   +11 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Evidence of blood–brain barrier dysfunction and CSF immunoglobulin synthesis in Down Syndrome Regression Disorder

Annals of Clinical and Translational Neurology
Objectives This study sought to evaluate proteomic, metabolomic, and immune signatures in the cerebrospinal fluid of individuals with Down Syndrome Regression Disorder (DSRD). Methods A prospective case–control study comparing proteomic, metabolomic, and
Jonathan D. Santoro, Neetha Paul Eduthan, Mellad M. Khoshnood, Saba Jafarpour, Natalie K. Boyd, Benjamin N. Vogel, Lina Nguyen, Lilia Kazerooni, Eleanor Britton, Hannah R. Lyford, Matthew D. Galbraith, Angela L. Rachubinski, Joaquin M. Espinosa   +12 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Voxel‐based dysconnectomic brain morphometry with computed tomography in Down syndrome

Annals of Clinical and Translational Neurology
Objective Alzheimer's disease (AD) is a major health concern for aging adults with Down syndrome (DS), but conventional diagnostic techniques are less reliable in those with severe baseline disability.
Beatriz Sánchez‐Moreno, Linda Zhang, Gloria Mateo, Fernando Moldenhauer, Mikael Brudfors, John Ashburner, Parashkev Nachev, Diego Real deAsúa, Bryan A. Strange   +8 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Socio-affective development in infants with Down' s Syndrome. 'Desarrollo socio-afectivo en niños con síndrome de Down'

, 1990
El libro es el resultado de la compilación de las colaboraciones de expertos internacionales reunidos en un Simposio Internacional sobre Psicología y Psicobiología Educativa e Integración Social de las personas con Síndrome de Down, organizado por Juan ...
Pérez López, Julio, Candel Gil, Isidoro, Carranza Carnicero, José Antonio   +2 more
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