Results 71 to 80 of about 3,268,379 (302)
The development of early expressive vocabulary in children with Down Syndrome [PDF]
, 2015 A delay in expressive language in children with Down Syndrome (DS) is common, and often a major challenge of the condition. This study aimed to investigate the early expressive vocabulary skills of Maltese children with DS, whose first languages were ...
Gatt, Daniela +2 more
core +1 more source
hbc/Molecular-convergence-between-Down-syndrome-and-Fragile-X-syndrome-hPSCs:
, 2022 Code repository for the paper "Molecular convergence between Down syndrome and Fragile X syndrome identified using human pluripotent stem cell ...
Victor Barrera
core +1 more source
Down Syndrome and COVID-19: A Perfect Storm?
Cell Reports Medicine, 2020 People with Down syndrome show signs of chronic immune dysregulation, including a higher prevalence of autoimmune disorders, increased rates of hospitalization during respiratory viral infections, and higher mortality rates from pneumonia and sepsis.
Joaquin M. Espinosa
doaj +1 more source
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo +5 more
wiley +1 more source
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Combining acetabular and femoral morphology improves our understanding of the down syndrome hip. [PDF]
, 2018 Background: Hip instability is frequent in patients with Down syndrome. Recent studies have suggested that skeletal hip alterations are responsible for this instability; however, there are currently no studies simultaneously assessing femoral and ...
ASSI, Ayman +7 more
core +1 more source
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2018 Introduction People with Down syndrome (DS) are at high risk for Alzheimer's disease (AD). Defects in monoamine neurotransmitter systems are implicated in DS and AD but have not been comprehensively studied in DS.
Alain D. Dekker +16 more
doaj +1 more source
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Prevalence and impact of X-ray screening for atlantoaxial instability in children with Down syndrome [PDF]
, 2021 Introduction: Atlantoaxial instability (AAI) is defined as excessive movement between the first and second cervical vertebra. This can lead to spinal cord compression, resulting in myelopathic and radicular symptoms.
Shenoda, Daniel
core +1 more source
iScienceSummary: Individuals with Down syndrome (DS), caused by trisomy of chromosome 21 (chr21, T21), are strongly predisposed to Alzheimer’s disease (AD), due to triplication of the APP gene, with ∼100% penetrance of AD brain pathology by age 40 and variable ...
Paula Araya +15 more
doaj +1 more source