Results 51 to 60 of about 609,367 (314)

Innate Immune System Activation and Neuroinflammation in Down Syndrome and Neurodegeneration: Therapeutic Targets or Partners?

Frontiers in Aging Neuroscience, 2021
Innate immune system activation and inflammation are associated with and may contribute to clinical outcomes in people with Down syndrome (DS), neurodegenerative diseases such as Alzheimer’s disease (AD), and normal aging.
Md. Mahiuddin Ahmed, Md. Mahiuddin Ahmed, Md. Mahiuddin Ahmed, Noah R. Johnson, Noah R. Johnson, Noah R. Johnson, Timothy D. Boyd, Timothy D. Boyd, Timothy D. Boyd, Christina Coughlan, Christina Coughlan, Christina Coughlan, Heidi J. Chial, Heidi J. Chial, Heidi J. Chial, Huntington Potter, Huntington Potter, Huntington Potter   +17 more
doaj   +1 more source

The language development of children with Down syndrome: First words to two-word phrases

, 1994
A longitudinal study was conducted to investigate the early language development of children with Down syndrome. Using parental records of their children's speech, the study investigated very early language development, from first words to the ...
Buckley, Sue, Oliver, Bonamy R
core   +1 more source

Efficacy and Safety Analysis of Roxarestat in Regulating Renal Anemia in Patients on Maintenance Hemodialysis

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Objective To compare the efficacy and safety of roxarestat versus recombinant human erythropoietin (rhEPO) in the management of renal anemia in patients undergoing maintenance hemodialysis. Methods This was a prospective, open‐label, randomized controlled trial.
Lingling Chen, Junjie Zhu, Qiaonan Ge
wiley   +1 more source

Multimodal analysis of dysregulated heme metabolism, hypoxic signaling, and stress erythropoiesis in Down syndrome

Cell Reports
Summary: Down syndrome (DS), the genetic condition caused by trisomy 21 (T21), is characterized by delayed neurodevelopment, accelerated aging, and increased risk of many co-occurring conditions.
Micah G. Donovan, Angela L. Rachubinski, Keith P. Smith, Paula Araya, Katherine A. Waugh, Belinda Enriquez-Estrada, Eleanor C. Britton, Hannah R. Lyford, Ross E. Granrath, Kyndal A. Schade, Kohl T. Kinning, Neetha Paul Eduthan, Kelly D. Sullivan, Matthew D. Galbraith, Joaquin M. Espinosa   +14 more
doaj   +1 more source

CDK8 Kinase Activity Promotes Glycolysis

Cell Reports, 2017
Summary: Aerobic glycolysis, also known as the Warburg effect, is a hallmark of cancerous tissues. Despite its importance in cancer development, our understanding of mechanisms driving this form of metabolic reprogramming is incomplete. We report here an
Matthew D. Galbraith, Zdenek Andrysik, Ahwan Pandey, Maria Hoh, Elizabeth A. Bonner, Amanda A. Hill, Kelly D. Sullivan, Joaquín M. Espinosa   +7 more
doaj   +1 more source

Therapeutic Apheresis for Intravenous Methylprednisolone‐Refractory Neuromyelitis Optica Spectrum Disorder: Clinical and Radiological Outcomes in a Single‐Center Case Series

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Neuromyelitis optica spectrum disorder (NMOSD) is a relapsing autoimmune disease of the central nervous system. High‐dose intravenous methylprednisolone (IVMP) is the standard first‐line therapy for acute attacks, although some patients remain refractory.
Wataru Horiguchi, Daisuke Katagiri, Takeyuki Watadani, Shunichi Matsuda, Hiroshi Kaneko, Noritoshi Arai   +5 more
wiley   +1 more source

Severely ill and high-risk COVID-19 patients exhibit increased peripheral circulation of CD62L+ and perforin+ T cells

Frontiers in Immunology, 2023
IntroductionThe emergence of SARS-CoV-2, which causes COVID-19, has led to over 400 million reported cases worldwide. COVID-19 disease ranges from asymptomatic infection to severe disease and may be impacted by individual immune differences.MethodsWe ...
Kelsey E. Lesteberg, Kelsey E. Lesteberg, Paula Araya, Katherine A. Waugh, Katherine A. Waugh, Lakshmi Chauhan, Joaquin M. Espinosa, Joaquin M. Espinosa, J. David Beckham, J. David Beckham, J. David Beckham, J. David Beckham   +11 more
doaj   +1 more source

Effects of the Fluid Replacement Method During Online Hemodiafiltration on the Solute Removal Performance and Biocompatibility Using the Asymmetric Cellulose Triacetate Membrane

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Pre‐dilution online hemodiafiltration (Pre‐HDF) is predominantly used in Japan, whereas post‐dilution online HDF (Post‐HDF) is more common in Europe. An asymmetric cellulose triacetate (ATA) membrane may improve biocompatibility.
Kenji Sakurai, Yoshitaka Kurihara, Fumi Yamauchi, Hiromi Hosoya, Takeshi Saito   +4 more
wiley   +1 more source

Does the well-being of individuals with Down syndrome and dementia improve when using life story books and rummage boxes? A randomised single case series experiment [PDF]

, 2015
Background: This study investigated whether a personalised life story book and rummage box enhanced well-being and led to changes in behaviour for people with Down syndrome (DS) who have dementia. Materials & Methods: A randomised single-case series
Langdon, Peter E., Crook, Nicola, Langdon, Peter E.; id_orcid, Adams, M., Shorten, Nicola, Crook, N., Shorten, N., Adams, Malcolm   +7 more
core   +1 more source

Region-specific slowing of alpha oscillations associated with visual-perceptual abilities in children born very preterm

Frontiers in Human Neuroscience, 2013
Children born very preterm (≤32 weeks GA) without major intellectual or neurological impairments often express selective deficits in visual-perceptual abilities.
Sam McLeod Doesburg, Alexander eMoiseev, Anthony T Herdman, Urs eRibary, Ruth Eckstein Grunau   +4 more
doaj   +1 more source