Results 61 to 70 of about 1,226,398 (302)

Effects of the Fluid Replacement Method During Online Hemodiafiltration on the Solute Removal Performance and Biocompatibility Using the Asymmetric Cellulose Triacetate Membrane

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Pre‐dilution online hemodiafiltration (Pre‐HDF) is predominantly used in Japan, whereas post‐dilution online HDF (Post‐HDF) is more common in Europe. An asymmetric cellulose triacetate (ATA) membrane may improve biocompatibility.
Kenji Sakurai, Yoshitaka Kurihara, Fumi Yamauchi, Hiromi Hosoya, Takeshi Saito   +4 more
wiley   +1 more source

Cross-syndrome comparison of real-world executive functioning and problem solving using a new problem-solving questionnaire [PDF]

, 2016
Background. Individuals with neurodevelopmental disorders like Williams syndrome and Down syndrome exhibit executive function impairments on experimental tasks (Lanfranchi, Jerman, Dal Pont, Alberti, & Vianello, 2010; Menghini, Addona, Costanzo, & Vicari,
Annette Karmiloff-Smith, Banich, Beck, Best, Bruininks, Bull, Burgess, Burgess, Camp, Capone, Carlson, Carney, Carr, Conners, Costanzo, Dunbar, Dunn, Dykens, Elison, Elliott, Emily K. Farran, Eysenck, Fidler, Field, Gioia, Goodman, Grace-Martin, Greer, Howlin, Joanne S. Camp, Joffe, John, Jurado, Kahney, Lanfranchi, Lee, Leyfer, Leyfer, Lott, McIntosh, Menghini, Mervis, Michael S.C. Thomas, Miyake, Mundy, Nevill, Newell, Pennington, Phillips, Pretz, Raven, Reed, Reitman, Rhodes, Shallice, Shallice, Sheldon, Silverman, Stinton, Stuss, Toplak, Unterrainer, Vandermorris, Woodruff-Borden   +63 more
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Trisomy 21 consistently activates the interferon response

eLife, 2016
Although it is clear that trisomy 21 causes Down syndrome, the molecular events acting downstream of the trisomy remain ill defined. Using complementary genomics analyses, we identified the interferon pathway as the major signaling cascade consistently ...
Kelly D Sullivan, Hannah C Lewis, Amanda A Hill, Ahwan Pandey, Leisa P Jackson, Joseph M Cabral, Keith P Smith, L Alexander Liggett, Eliana B Gomez, Matthew D Galbraith, James DeGregori, Joaquín M Espinosa   +11 more
doaj   +1 more source

Perceptions and discourses relating to genetic testing : interviews with people with Down syndrome [PDF]

, 2016
Background: The perceptions of individuals with Down syndrome are conspicuously absent in discussions about the use of prenatal testing. Method: Eight individuals with Down syndrome were interviewed about their views and experience of the topic ...
Barter, B., Hastings, Richard P., Huws, J., Williams, R. R.   +3 more
core   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

JAK inhibition decreases the autoimmune burden in Down syndrome

eLife
Background: Individuals with Down syndrome (DS), the genetic condition caused by trisomy 21 (T21), display clear signs of immune dysregulation, including high rates of autoimmunity and severe complications from infections. Although it is well established
Angela L Rachubinski, Elizabeth Wallace, Emily Gurnee, Belinda A Enriquez-Estrada, Kayleigh R Worek, Keith P Smith, Paula Araya, Katherine A Waugh, Ross E Granrath, Eleanor Britton, Hannah R Lyford, Micah G Donovan, Neetha Paul Eduthan, Amanda A Hill, Barry Martin, Kelly D Sullivan, Lina Patel, Deborah J Fidler, Matthew D Galbraith, Cory A Dunnick, David A Norris, Joaquín M Espinosa   +21 more
doaj   +1 more source

Web Untuk Deteksi Dini Tingkat Retardasi Down Syndrome Pada Anak [PDF]

, 2015
Down Syndrome is a condition of physical and mental development's retardation in children that caused by abnormalities in the development of the chromosome. However, behind the special needs held by children with Down syndrome, they have a chance to live
Leonita, C. (Christine), Sevani, N. (Nina)   +1 more
core  

Evaluation of a usability testing guide for mobile applications focused on people with Down syndrome (USATESTDOWN) [PDF]

, 2016
Usability testing of mobile applications involving people with Down syndrome is an issue that has not been comprehensively investigated. There is no single proposal that takes on board all the issues that could potentially be taken into account to deal ...
Alamán Roldán, Xavier, Cáliz Ramos, Doris Cruz, Cáliz Ramos, Richarth Harold, Gómez Escribano, Javier, Martínez Normand, Loïc, Terán Villamarín, Carlos   +5 more
core   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source