Results 61 to 70 of about 3,268,379 (302)

Altered hepatic metabolism in Down syndrome

Cell Reports
Summary: Trisomy 21 (T21) gives rise to Down syndrome (DS), the most commonly occurring chromosomal abnormality in humans. T21 affects nearly every organ and tissue system in the body, predisposing individuals with DS to congenital heart defects ...
Lauren N. Dunn, Brian F. Niemeyer, Neetha P. Eduthan, Kyndal A. Schade, Katherine A. Waugh, Chrisstopher Brown, Angela L. Rachubinski, Ariel E. Timkovich, David J. Orlicky, Matthew D. Galbraith, Joaquin M. Espinosa, Kelly D. Sullivan   +11 more
doaj   +1 more source

Therapeutic Apheresis in Nigeria: A Multi‐Center Summary of Abstracts From the Inaugural Nigerian Society for Apheresis Scientific Meeting

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Therapeutic apheresis (TA) is an established treatment modality for hematologic, neurologic, and immunologic disorders, yet access remains severely limited in sub‐Saharan Africa. Donor apheresis, including platelet apheresis collection from healthy donors, represents an important complementary modality supporting blood product ...
Nosa Bazuaye, Chimezie Okwuonu, Evelyn Idam, Folasade Adelekan‐Popoola, Shakirat Gold‐Olufadi, Olufunto Olufela Kalejaiye, Abdullateef Ogala, Zinnah Aloziem, Blossom Amamchukwu, Patience Elimia, Mkpoikanabasi Obot‐Obot, Henry Mbakwe, Praises Maduagwuna, Olatunji Akinrodoye, Chiamaka Anyanwu, Benjamin Anyanwu, Adedamola Akinsiku, Oluwatoyin A. Akinsiku, Muzamil O. Hassan, Fatiu A. Arogundade, Olalekan E. Ojo, Homayemem Weli, Jesupelumi Adenihun, Aderemi Adelaja, Ebun Bamgboye, Olalekan Olatise, Ade E. Faponle, Ayoola Odeyemi, Michael Muoka, Stephen Asaolu, Qudrat Busari, Blessing Dawudu, Michael Naiyeju, Rasheed A. Balogun   +33 more
wiley   +1 more source

Impairments in motor coordination without major changes in cerebellar plasticity in the Tc1 mouse model of Down syndrome [PDF]

, 2009
Down syndrome (DS) is a genetic disorder arising from the presence of a third copy of human chromosome 21 (Hsa21). Recently, O’Doherty et al. [An aneuploid mouse strain carrying human chromosome 21 with Down syndrome phenotypes. Science 309 (2005) 2033–
Bliss, T. V.P., Daniel, Herve, Fisher, E. M.C., Morice, Elise, Daniel, H., Bliss, T.V.P., Fisher, Elizabeth MC, Jani, H., Galante, Micaela, Vanes, Lesley, Bliss, Timothy VP, Galante, M., Morice, E., Vanes, L., Tybulewicz, V.L.J., Tybulewicz, V. L.J., Fisher, E.M.C., Jani, Harsha, Tybulewicz, Victor LJ   +18 more
core   +1 more source

Web access experiences of people with Down syndrome

, 2022
Social integration is now the norm for many children and adults with Down syndrome. Many persons with Down syndrome are interested in being active members of society.
Rodríguez Baena, Luis, González-Crespo, Rubén, Alonso-Virgós, Lucía, Pascual Espada, Jordán   +3 more
core   +1 more source

JAK inhibition decreases the autoimmune burden in Down syndrome

eLife
Background: Individuals with Down syndrome (DS), the genetic condition caused by trisomy 21 (T21), display clear signs of immune dysregulation, including high rates of autoimmunity and severe complications from infections. Although it is well established
Angela L Rachubinski, Elizabeth Wallace, Emily Gurnee, Belinda A Enriquez-Estrada, Kayleigh R Worek, Keith P Smith, Paula Araya, Katherine A Waugh, Ross E Granrath, Eleanor Britton, Hannah R Lyford, Micah G Donovan, Neetha Paul Eduthan, Amanda A Hill, Barry Martin, Kelly D Sullivan, Lina Patel, Deborah J Fidler, Matthew D Galbraith, Cory A Dunnick, David A Norris, Joaquín M Espinosa   +21 more
doaj   +1 more source

Trisomy 21 consistently activates the interferon response

eLife, 2016
Although it is clear that trisomy 21 causes Down syndrome, the molecular events acting downstream of the trisomy remain ill defined. Using complementary genomics analyses, we identified the interferon pathway as the major signaling cascade consistently ...
Kelly D Sullivan, Hannah C Lewis, Amanda A Hill, Ahwan Pandey, Leisa P Jackson, Joseph M Cabral, Keith P Smith, L Alexander Liggett, Eliana B Gomez, Matthew D Galbraith, James DeGregori, Joaquín M Espinosa   +11 more
doaj   +1 more source

Establishing an Apheresis Medicine Program in a Resource‐Constrained Setting: A 5‐Year Experience From Lagos, Nigeria

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Establishing a comprehensive apheresis medicine program in a resource‐constrained setting presents significant structural, financial, and logistical challenges. Despite the growing clinical importance of apheresis services globally, published experience from sub‐Saharan Africa remains sparse.
Folasade Adelekan‐Popoola, Shakirat Gold‐Olufadi, Olufunto Olufela Kalejaiye, Abdullateef Ogala, Rasheed A. Balogun   +4 more
wiley   +1 more source

Pediatric Mediastinal Gray Zone Lymphoma With Germline TET2 Heterozygous Variant

Pediatric Blood &Cancer, EarlyView.
Matthew R. Schuelke, Julia Wang, Haley Newman, Evelyn Kurpiewski, Anne Reilly, Susan R. Rheingold, Gerald Wertheim, Moe Takeda, Daniel J. Zheng, Kaitlin Devine   +9 more
wiley   +1 more source

Serum Myonectin Levels Are Positively Associated With Physical Function and Lower Frailty‐Related Limitation in Maintenance Hemodialysis Patients: A Cross‐Sectional Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Maintenance hemodialysis (MHD) patients frequently suffer from frailty, characterized by reduced physical function and poor prognosis. Myokines, such as myonectin, secreted by muscle, are emerging regulators of systemic health. This study investigated the relationship between serum myonectin, adipokines (adiponectin, omentin), and ...
Kenichi Kono, Yoshifumi Moriyama, Koji Ohashi, Naoya Otaka, Minako Tatsumi, Toyoaki Murohara, Noriyuki Ouchi, Satoru Oshima   +7 more
wiley   +1 more source

Perceptual-motor deficits in children with Down syndrome: Implications for intervention [PDF]

, 2006
– Early intervention approaches for facilitating motor development in infants and children with Down syndrome have traditionally emphasised the acquisition of motor milestones. As increasing evidence suggests that motor milestones have limited predictive
Asha Kapur, Kimberly Kerns, Eric Zhou, Naznin Virji-babul   +3 more
core