Results 81 to 90 of about 1,226,398 (302)
Alzheimer’s Research & Therapy, 2020 Background Down syndrome (DS) is the most common genetic cause of Alzheimer’s disease (AD), but diagnosis of AD in DS is challenging due to the intellectual disability which accompanies DS.
David Mengel +10 more
doaj +1 more source
HUBUNGAN LINGKAR KEPALA DENGAN PERKEMBANGAN ANAK SINDROM DOWN [PDF]
, 2015 Background: Down syndrome is congenital disease caused by abnormalities in 21st chromosome. Small head circumference and developmental delay are characteristics of children with Down Syndrome.
Purwanti, Asri, Sishadi, Arla Santika
core
Narrative language competence in children and adolescents with Down syndrome [PDF]
, 2015 This study was designed to examine the narrative language abilities of children and adolescents with Down syndrome in comparison to same-age peers with fragile X syndrome and younger typically developing children matched by nonverbal cognitive ability ...
Andrea S McDuffie +4 more
core +2 more sources
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
PENERIMAAN DIRI ORANG TUA YANG MEMILIKI ANAK DOWN SYNDROME [PDF]
, 2016 Orang tua yang memiliki anak down syndrome tidak semuanya mengalami dan merasakan hal yang sama terhadap kehadiran anaknya yang down syndrome, ada beberapa orang tua yang menerima anaknya dengan segala kekurangannya sedangkan ada juga orang tua yang ...
Dekalia Yulistiani
core
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Chromosome Instability and Mosaic Aneuploidy in Neurodegenerative and Neurodevelopmental Disorders
Frontiers in Genetics, 2019 Evidence from multiple laboratories has accumulated to show that mosaic neuronal aneuploidy and consequent apoptosis characterizes and may underlie neuronal loss in many neurodegenerative diseases, particularly Alzheimer’s disease and frontotemporal ...
Huntington Potter +12 more
doaj +1 more source
Distribusi Penderita Sindrom Down Berdasarkan Analisis Sitogenetika Di Laboratorium CEBIOR [PDF]
, 2015 Background : Down syndrome is a condition when a person has an extra number of chromosomes 21 in the form of either classical trisomy 21, translocation or mosaic.
Berlinda, Impi +2 more
core +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Epileptic spasms in individuals with Down syndrome: A review of the current literature
Epilepsia Open, 2020 Epilepsy can occur in individuals with Down syndrome (DS), with epileptic spasms representing the most frequent seizure type in this population. Epileptic spasms can have devastating consequences on the development of individuals with the condition. This
Daniel J. Kats +2 more
doaj +1 more source