Results 81 to 90 of about 609,367 (314)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Chromosome Instability and Mosaic Aneuploidy in Neurodegenerative and Neurodevelopmental Disorders

Frontiers in Genetics, 2019
Evidence from multiple laboratories has accumulated to show that mosaic neuronal aneuploidy and consequent apoptosis characterizes and may underlie neuronal loss in many neurodegenerative diseases, particularly Alzheimer’s disease and frontotemporal ...
Huntington Potter, Huntington Potter, Heidi J. Chial, Heidi J. Chial, Julbert Caneus, Mihret Elos, Mihret Elos, Nina Elder, Nina Elder, Sergiy Borysov, Antoneta Granic, Antoneta Granic, Antoneta Granic   +12 more
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Epileptic spasms in individuals with Down syndrome: A review of the current literature

Epilepsia Open, 2020
Epilepsy can occur in individuals with Down syndrome (DS), with epileptic spasms representing the most frequent seizure type in this population. Epileptic spasms can have devastating consequences on the development of individuals with the condition. This
Daniel J. Kats, Katherine J. Roche, Brian G. Skotko   +2 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Epidemiology of Down syndrome

, 2009
In literature the ratio of Down Syndrome (DS) newborns is usually 1:1,000. A lot of papers relate none differences about geographical distribution or differences for race.
S. Forti, U. Ambrosetti
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Complicating a rudimentary list of characteristics: Communicating disability with down syndrome dolls

, 2012
Apparently some people upon coming across [Down Syndrome dolls] were offended. […] Still, it’s curious, and telling, what gives offense. Was it the shock of seeing a doll not modeled on the normative form that caused such offense?
Ellis, K.
core  

Prevalence and impact of X-ray screening for atlantoaxial instability in children with Down syndrome [PDF]

, 2021
Introduction: Atlantoaxial instability (AAI) is defined as excessive movement between the first and second cervical vertebra. This can lead to spinal cord compression, resulting in myelopathic and radicular symptoms.
Shenoda, Daniel
core  

University Students' Attitudes Towards Individuals with Disabilities and Their Education in Türkiye: The Case of a Private Non-Profit University

International Journal of Turkish Education Sciences
The readiness levels of the university environment play a crucial role in enabling individuals with disabilities to benefit more from higher education.
Özlem Özaydın, Yunus Emre Aydın, Döne Kaplan, Gülhan Kalmuk, Mehmet Emin Mansurgüler   +4 more
doaj   +1 more source