Adopting Children with Down Syndrome: A qualitative study of family experiences [PDF]
, 2017 The purpose of this study is to qualitatively investigate and compare the family beliefs, values, and perceptions of parenting of families who have adopted children with Down syndrome (DS) to parents who have biological children with DS.
Richter, Emily L
core +2 more sources
Adults with Down syndrome: a comprehensive approach to manage complexity [PDF]
, 2019 Angelo Carfì +10 more
openalex +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Penanganan Kognitif Anak Down Syndrome Melalui Metode Kartu Warna Di TK Permata Bunda Surakarta Tahun Ajaran 2013/2014 [PDF]
, 2013 Penelitian ini dilatarbekangi adanya perilaku anak penyandang down syndrome terhadap kemampuan kognitifnya dalam hal pengenalan warna. Sehingga peneliti berusaha untuk menerapkan metode kartu warna untuk penanganan kemampuan kognitif pada anak down ...
, Dra. Surtikanti M. Pd +1 more
core
Interplay between RNA‐protein interactions and RNA structures in gene regulation
FEBS Open Bio, EarlyView.Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko +2 more
wiley +1 more source
Neurobiology of DiseaseAquaporin-4 (AQP4) is implicated in Alzheimer's disease (AD) pathology through its role in astrocytic function, cerebrovascular integrity, and beta-amyloid (Aβ) clearance.
Cherie A. Stringer +21 more
doaj +1 more source
Learning to read in regular and special schools: a follow up study of students with Down Syndrome [PDF]
, 2015 In 2006, a questionnaire was sent to 160 parents of children with Down syndrome in Dutch primary education (special and regular) with a response rate of 76%.
De graaf, Gert, Van Hove, Geert
core
Homologous expression and purification of human HAX‐1 for structural studies
FEBS Open Bio, EarlyView.This research protocol provides detailed instructions for cloning, expressing, and purifying large quantities of the intrinsically disordered human HAX‐1 protein, N‐terminally fused to a cleavable superfolder GFP, from mammalian cells. HAX‐1 is predicted to undergo posttranslational modifications and to interact with membranes, various cellular ...
Mariana Grieben
wiley +1 more source
KEMAMPUAN MORFOLOGIS PADA TUTURAN ANAK DOWN SYNDROME YANG TERGOLONG MAMPU LATIH [PDF]
, 2014 Penelitian ini dilatarbelakangi permasalahan seputar keterbatasan atas kemampuan morfologis yang dimiliki oleh anak down syndrome yang tergolong mampu latih. Tujuan dari penelitian ini adalah 1) mengetahui kemampuan pembentukan afiksasi pada tuturan anak
Dewi, Yesi Fitria
core