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Public Health Genomics, 1999 <i>Objective:</i> To investigate the effect of parity on Down syndrome (DS). <i>Methods:</i> The study was conducted on data from Northeast Italy (NEI) (1981–1996) and Sicily (ISMAC) (1991–1996) Congenital Malformation Registries.
CLEMENTI, MAURIZIO +4 more
openaire +4 more sources
Cognitive and social factors in the development of infants with Down syndrome [PDF]
, 2002 Infants and young children with Down syndrome can be engaging and affectionate. It seems that in the early months of life their personal relations may be relatively 'spared' the effects of limitations in their capacities for information-processing.
Oates, John M. +3 more
core +4 more sources
Down syndrome, paternal age and education: comparison of California and the Czech Republic [PDF]
, 2005 Background: The association between maternal age and risk of Down syndrome has been repeatedly shown in various populations. However, the effect of paternal age and education of parents has not been frequently studied.
Hynek Pikhart +5 more
core +2 more sources
Down syndrome-recent progress and future prospects [PDF]
, 2009 Down syndrome (DS) is caused by trisomy of chromosome 21 (Hsa21) and is associated with a number of deleterious phenotypes, including learning disability, heart defects, early-onset Alzheimer's disease and childhood leukaemia.
K. A. Alford +11 more
core +1 more source
Health comorbidities and cognitive abilities across the lifespan in Down syndrome
Journal of Neurodevelopmental Disorders, 2020 Background Down syndrome (DS) is associated with variable intellectual disability and multiple health and psychiatric comorbidities. The impact of such comorbidities on cognitive outcomes is unknown.
Carla M. Startin +10 more
doaj +1 more source
Language in aging persons with Down syndrome [PDF]
, 2002 peer reviewedSeveral cross-sectional studies and one longitudinal study were conducted on the language abilities of various cohorts of persons with Down syndrome aged between 14 and 50 years. No significant difference was observed on any of the receptive
Comblain, Annick +3 more
core +1 more source
Modelling Down Syndrome leukaemia using transchromosomic ES cell lines. [PDF]
, 2009 PhDAMKL (acute megakaryoblastic leukaemia) accounts for at least 50% of all cases of acute myeloid leukaemia (AML) associated with Down Syndrome (DS). Every tenth neonate with DS develops Transient Myeloproliferative Disorder (TMD), a self-regressing
De Vita, Serena
core +4 more sources
JAK1 Inhibition Blocks Lethal Immune Hypersensitivity in a Mouse Model of Down Syndrome
Cell Reports, 2020 Summary: Individuals with Down syndrome (DS; trisomy 21) display hyperactivation of interferon (IFN) signaling and chronic inflammation, which could potentially be explained by the extra copy of four IFN receptor (IFNR) genes encoded on chromosome 21 ...
Kathryn D. Tuttle +15 more
doaj +1 more source
Arthropathy of down's syndrome [PDF]
Arthritis & Rheumatism, 1984 AbstractDown's syndrome (trisomy 21) is associated with a variety of skeletal abnormalities and an increased incidence of joint hypermobility. Children with Down's syndrome are known to have a number of immunologic abnormalities and an increased incidence of autoimmune phenomena. We report 7 patients with Down's syndrome and arthritis.
C L, Yancey +3 more
openaire +2 more sources
Journal of Patient-Centered Research and Reviews, 2021 Purpose: Given the current life expectancy and number of individuals living with Down syndrome (DS), it is important to learn common occurrences of disease conditions across the developmental lifespan.
Brian Chicoine +5 more
doaj +1 more source