Results 21 to 30 of about 3,268,379 (302)

Red blood cell metabolism in Down syndrome: hints on metabolic derangements in aging

Blood Advances, 2017
: Red blood cells (RBCs) are the most abundant cell in the human body. During their ∼120-day life span in the circulatory system, RBCs release oxygen to all human tissues while being exposed to tissue metabolic activity.
Rachel Culp-Hill, Connie Zheng, Julie A. Reisz, Keith Smith, Angela Rachubinski, Travis Nemkov, Eric Butcher, Ross Granrath, Kirk C. Hansen, Joaquín M. Espinosa, Angelo D'Alessandro   +10 more
doaj   +1 more source

Prevalence of Mental Health Conditions Among 6078 Individuals With Down Syndrome in the United States

Journal of Patient-Centered Research and Reviews, 2022
Findings from a recent study of the largest documented cohort of individuals with Down syndrome (DS) in the United States described prevalence of common disease conditions and strongly suggested significant disparity in mental health conditions among ...
Anne Rivelli, Veronica Fitzpatrick, Sagar Chaudhari, Laura Chicoine, Gengjie Jia, Andrey Rzhetsky, Brian Chicoine   +6 more
doaj   +1 more source

Prevalence of Endocrine Disorders Among 6078 Individuals With Down Syndrome in the United States

Journal of Patient-Centered Research and Reviews, 2022
Findings from a recent study describing prevalence of common disease conditions in the largest documented cohort of individuals with Down syndrome (DS) in the United States strongly suggested significant disparity in endocrine disorders among these ...
Anne Rivelli, Veronica Fitzpatrick, Danielle Wales, Laura Chicoine, Gengjie Jia, Andrey Rzhetsky, Brian Chicoine   +6 more
doaj   +1 more source

Prevalence of Infectious Diseases Among 6078 Individuals With Down Syndrome in the United States

Journal of Patient-Centered Research and Reviews, 2022
A recent disease prevalence study of the largest documented Down syndrome (DS) cohort in the United States strongly suggested significant disparity in general infectious disease conditions among individuals with DS versus those without DS. In this follow-
Veronica Fitzpatrick, Anne Rivelli, Sagar Chaudhari, Laura Chicoine, Gengjie Jia, Andrey Rzhetsky, Brian Chicoine   +6 more
doaj   +1 more source

Seroconversion stages COVID19 into distinct pathophysiological states

eLife, 2021
COVID19 is a heterogeneous medical condition involving diverse underlying pathophysiological processes including hyperinflammation, endothelial damage, thrombotic microangiopathy, and end-organ damage.
Matthew D Galbraith, Kohl T Kinning, Kelly D Sullivan, Ryan Baxter, Paula Araya, Kimberly R Jordan, Seth Russell, Keith P Smith, Ross E Granrath, Jessica R Shaw, Monika Dzieciatkowska, Tusharkanti Ghosh, Andrew A Monte, Angelo D'Alessandro, Kirk C Hansen, Tellen D Benett, Elena WY Hsieh, Joaquín M Espinosa   +17 more
doaj   +1 more source

Aging and Down Syndrome [PDF]

Current Gerontology and Geriatrics Research, 2012
The initial clinical description of Down syndrome (DS) was made by Down in 1866 [1] and identified as trisomy of chromosome 21 by Lejeune et al. in 1959 [2]. DS, or trisomy 21, is one of the most common causes of intellectual disability (ID), and recent national prevalence estimates suggest that 14.47 per 10,000 live births are infants with DS, leading
Elizabeth Head, Wayne Silverman, David Patterson, Ira T. Lott   +3 more
openaire   +2 more sources

Epidemiology of Down syndrome

, 2009
In literature the ratio of Down Syndrome (DS) newborns is usually 1:1,000. A lot of papers relate none differences about geographical distribution or differences for race.
S. Forti, U. Ambrosetti
core   +2 more sources

The innate immune system stimulating cytokine GM-CSF improves learning/memory and interneuron and astrocyte brain pathology in Dp16 Down syndrome mice and improves learning/memory in wild-type mice

Neurobiology of Disease, 2022
Down syndrome (DS) is characterized by chronic neuroinflammation, peripheral inflammation, astrogliosis, imbalanced excitatory/inhibitory neuronal function, and cognitive deficits in both humans and mouse models.
Md. Mahiuddin Ahmed, Athena Ching-Jung Wang, Mihret Elos, Heidi J. Chial, Stefan Sillau, D. Adriana Solano, Christina Coughlan, Leila Aghili, Paige Anton, Neil Markham, Vanesa Adame, Katheleen J. Gardiner, Timothy D. Boyd, Huntington Potter   +13 more
doaj   +1 more source

Opioids and Down’s syndrome

Journal of Opioid Management, 2006
Opioids are used in clinical practice for sedation, anesthesia, and analgesia. Their effects depend on their pharmacokinetic and pharmacodynamic characteristics. The liver is the major site for the biotransformation of most opioids. The major metabolic pathway is oxidation.
F. Mafrica, FODALE, Vincenzo
openaire   +6 more sources

Another side to their story: including people with Down syndrome in an initial exploration of the social fabric of their emotional well-being [PDF]

, 2016
The project ran as part of the Community Academic Research Links CARL programme in University College Cork. Down Syndrome Cork were the community organisation. They provide support and services to adults and children with Down syndrome and their families
Dunphy, Sarah
core   +1 more source