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The co-construction of a reading assessment measure with adults with Down syndrome: a meaningful literacy approach

Frontiers in Psychology, 2023
IntroductionThe need to develop appropriate measures of broad-based reading-related literacy skills for adults with Down syndrome has been highlighted in the literature.
Pauline Frizelle, Sean O’Donovan, Mary Jolley, Lisa Martin, Nicola Hart   +4 more
doaj   +1 more source

Pain in Down's Syndrome [PDF]

The Scientific World JOURNAL, 2006
Pain is a homeostatic mechanism that intervenes to protect the organism from harmful stimuli that could damage its integrity. It is made up of two components: the sensory-discriminative component, which identifies the provenance and characteristics of the type of pain; and the affective-motivational component, on which emotional reflexes, following the
F. Mafrica, D. Schifilliti, FODALE, Vincenzo   +2 more
openaire   +5 more sources

Down syndrome-recent progress and future prospects [PDF]

, 2009
Down syndrome (DS) is caused by trisomy of chromosome 21 (Hsa21) and is associated with a number of deleterious phenotypes, including learning disability, heart defects, early-onset Alzheimer's disease and childhood leukaemia.
K. A. Alford, Wiseman, FK, Tybulewicz, VLJ, Wiseman, Frances K, Fisher, Elizabeth MC, E. M.C. Fisher, Alford, Kate A, Fisher, EMC, F. K. Wiseman, Alford, KA, Tybulewicz, Victor LJ, V. L.J. Tybulewicz   +11 more
core   +1 more source

Health comorbidities and cognitive abilities across the lifespan in Down syndrome

Journal of Neurodevelopmental Disorders, 2020
Background Down syndrome (DS) is associated with variable intellectual disability and multiple health and psychiatric comorbidities. The impact of such comorbidities on cognitive outcomes is unknown.
Carla M. Startin, Hana D’Souza, George Ball, Sarah Hamburg, Rosalyn Hithersay, Kate M. O. Hughes, Esha Massand, Annette Karmiloff-Smith, Michael S. C. Thomas, LonDownS Consortium, Andre Strydom   +10 more
doaj   +1 more source

Language in aging persons with Down syndrome [PDF]

, 2002
peer reviewedSeveral cross-sectional studies and one longitudinal study were conducted on the language abilities of various cohorts of persons with Down syndrome aged between 14 and 50 years. No significant difference was observed on any of the receptive
Comblain, Annick, Rondal, Jean-Adolphe, Annick Comblain, Jean Rondal   +3 more
core   +1 more source

JAK1 Inhibition Blocks Lethal Immune Hypersensitivity in a Mouse Model of Down Syndrome

Cell Reports, 2020
Summary: Individuals with Down syndrome (DS; trisomy 21) display hyperactivation of interferon (IFN) signaling and chronic inflammation, which could potentially be explained by the extra copy of four IFN receptor (IFNR) genes encoded on chromosome 21 ...
Kathryn D. Tuttle, Katherine A. Waugh, Paula Araya, Ross Minter, David J. Orlicky, Michael Ludwig, Zdenek Andrysik, Matthew A. Burchill, Beth A.J. Tamburini, Colin Sempeck, Keith Smith, Ross Granrath, Dayna Tracy, Jessica Baxter, Joaquin M. Espinosa, Kelly D. Sullivan   +15 more
doaj   +1 more source

Prevalence of Common Disease Conditions in a Large Cohort of Individuals With Down Syndrome in the United States

Journal of Patient-Centered Research and Reviews, 2021
Purpose: Given the current life expectancy and number of individuals living with Down syndrome (DS), it is important to learn common occurrences of disease conditions across the developmental lifespan.
Brian Chicoine, Anne Rivelli, Veronica Fitzpatrick, Laura Chicoine, Gengjie Jia, Andrey Rzhetsky   +5 more
doaj   +1 more source

Arthropathy of down's syndrome [PDF]

Arthritis & Rheumatism, 1984
AbstractDown's syndrome (trisomy 21) is associated with a variety of skeletal abnormalities and an increased incidence of joint hypermobility. Children with Down's syndrome are known to have a number of immunologic abnormalities and an increased incidence of autoimmune phenomena. We report 7 patients with Down's syndrome and arthritis.
C L, Yancey, C, Zmijewski, B H, Athreya, R A, Doughty   +3 more
openaire   +2 more sources

Red blood cell metabolism in Down syndrome: hints on metabolic derangements in aging

Blood Advances, 2017
: Red blood cells (RBCs) are the most abundant cell in the human body. During their ∼120-day life span in the circulatory system, RBCs release oxygen to all human tissues while being exposed to tissue metabolic activity.
Rachel Culp-Hill, Connie Zheng, Julie A. Reisz, Keith Smith, Angela Rachubinski, Travis Nemkov, Eric Butcher, Ross Granrath, Kirk C. Hansen, Joaquín M. Espinosa, Angelo D'Alessandro   +10 more
doaj   +1 more source

Prevalence of Infectious Diseases Among 6078 Individuals With Down Syndrome in the United States

Journal of Patient-Centered Research and Reviews, 2022
A recent disease prevalence study of the largest documented Down syndrome (DS) cohort in the United States strongly suggested significant disparity in general infectious disease conditions among individuals with DS versus those without DS. In this follow-
Veronica Fitzpatrick, Anne Rivelli, Sagar Chaudhari, Laura Chicoine, Gengjie Jia, Andrey Rzhetsky, Brian Chicoine   +6 more
doaj   +1 more source