Results 21 to 30 of about 4,821,896 (384)
Immune Dysregulation in Children With Down Syndrome
Frontiers in Pediatrics, 2020 Down syndrome (DS) is the most common genetic syndrome associated with immune defects. The extent of immune dysregulation in DS is substantial, spanning the innate and adaptive systems and including anomalies in: T and B cells, monocytes, neutrophil ...
D. Huggard, D. Doherty, E. Molloy
semanticscholar +1 more source
Nature Communications, 2022 The authors describe a functional crosstalk between the p53 network and the integrated stress response through the p53 repressor PPM1D. Inhibition of PPM1D potentiates p53-dependent transactivation and apoptosis via induction of the HRI-eIF2α-ATF4 ...
Zdenek Andrysik +3 more
doaj +1 more source
Evolution of neuroinflammation across the lifespan of individuals with Down syndrome.
Brain : a journal of neurology, 2020 Epidemiological and experimental studies suggest that a disease-aggravating neuroinflammatory process is present at preclinical stages of Alzheimer's disease.
Lisi Flores-Aguilar +9 more
semanticscholar +1 more source
F1000Research, 2016 Down syndrome (DS), which arises from trisomy of chromosome 21, is associated with deposition of large amounts of amyloid within the central nervous system.
Lewis Buss +6 more
doaj +1 more source
Health comorbidities and cognitive abilities across the lifespan in Down syndrome
Journal of Neurodevelopmental Disorders, 2020 Background Down syndrome (DS) is associated with variable intellectual disability and multiple health and psychiatric comorbidities. The impact of such comorbidities on cognitive outcomes is unknown.
Carla M. Startin +10 more
doaj +1 more source
Amyloid plaque core protein in Alzheimer disease and Down syndrome.
Proceedings of the National Academy of Sciences of the United States of America, 1985 We have purified and characterized the cerebral amyloid protein that forms the plaque core in Alzheimer disease and in aged individuals with Down syndrome. The protein consists of multimeric aggregates of a polypeptide of about 40 residues (4 kDa).
C. Masters +5 more
semanticscholar +1 more source
Journal of Patient-Centered Research and Reviews, 2021 Purpose: Given the current life expectancy and number of individuals living with Down syndrome (DS), it is important to learn common occurrences of disease conditions across the developmental lifespan.
Brian Chicoine +5 more
doaj +1 more source
Journal of Patient-Centered Research and Reviews, 2022 Findings from a recent study of the largest documented cohort of individuals with Down syndrome (DS) in the United States described prevalence of common disease conditions and strongly suggested significant disparity in mental health conditions among ...
Anne Rivelli +6 more
doaj +1 more source
Prevalence of Endocrine Disorders Among 6078 Individuals With Down Syndrome in the United States
Journal of Patient-Centered Research and Reviews, 2022 Findings from a recent study describing prevalence of common disease conditions in the largest documented cohort of individuals with Down syndrome (DS) in the United States strongly suggested significant disparity in endocrine disorders among these ...
Anne Rivelli +6 more
doaj +1 more source
Prevalence of Infectious Diseases Among 6078 Individuals With Down Syndrome in the United States
Journal of Patient-Centered Research and Reviews, 2022 A recent disease prevalence study of the largest documented Down syndrome (DS) cohort in the United States strongly suggested significant disparity in general infectious disease conditions among individuals with DS versus those without DS. In this follow-
Veronica Fitzpatrick +6 more
doaj +1 more source