Results 21 to 30 of about 1,249,164 (307)

Health comorbidities and cognitive abilities across the lifespan in Down syndrome

Journal of Neurodevelopmental Disorders, 2020
Background Down syndrome (DS) is associated with variable intellectual disability and multiple health and psychiatric comorbidities. The impact of such comorbidities on cognitive outcomes is unknown.
Carla M. Startin, Hana D’Souza, George Ball, Sarah Hamburg, Rosalyn Hithersay, Kate M. O. Hughes, Esha Massand, Annette Karmiloff-Smith, Michael S. C. Thomas, LonDownS Consortium, Andre Strydom   +10 more
doaj   +1 more source

On the origin of trisomy 21 Down syndrome [PDF]

, 2008
Background: Down syndrome, characterized by an extra chromosome 21 is the most common genetic cause for congenital malformations and learning disability.
Hultén, Maj A., Iwarsson, Erik, Jonsson, Anna Maria, Papadogiannakis, Nikos, Patel, Suketu D., Tankimanova, Maira, Westgren, Magnus   +6 more
core   +2 more sources

JAK1 Inhibition Blocks Lethal Immune Hypersensitivity in a Mouse Model of Down Syndrome

Cell Reports, 2020
Summary: Individuals with Down syndrome (DS; trisomy 21) display hyperactivation of interferon (IFN) signaling and chronic inflammation, which could potentially be explained by the extra copy of four IFN receptor (IFNR) genes encoded on chromosome 21 ...
Kathryn D. Tuttle, Katherine A. Waugh, Paula Araya, Ross Minter, David J. Orlicky, Michael Ludwig, Zdenek Andrysik, Matthew A. Burchill, Beth A.J. Tamburini, Colin Sempeck, Keith Smith, Ross Granrath, Dayna Tracy, Jessica Baxter, Joaquin M. Espinosa, Kelly D. Sullivan   +15 more
doaj   +1 more source

Prevalence of Common Disease Conditions in a Large Cohort of Individuals With Down Syndrome in the United States

Journal of Patient-Centered Research and Reviews, 2021
Purpose: Given the current life expectancy and number of individuals living with Down syndrome (DS), it is important to learn common occurrences of disease conditions across the developmental lifespan.
Brian Chicoine, Anne Rivelli, Veronica Fitzpatrick, Laura Chicoine, Gengjie Jia, Andrey Rzhetsky   +5 more
doaj   +1 more source

Parents’ experiences of health visiting for children with Down syndrome [PDF]

, 2018
© MA Healthcare Limited.Children with Down syndrome have an increased likelihoodof experiencing serious health conditions. Health visitors canhave an important role in monitoring and promoting healthand development for young children with Down syndrome ...
Braun V, Bull MJ, Cleves MA, Dawson AL, Douglas T, Gammons S, Geelhoed EA, Greenway JC, Ibesaine L., Marshall J, McCabe LL, McGrath RJ, Mengoni SE, Minnes P, Muggli EE, Murphy N, Peckover S., Schieve LA, Skotko BG., Skotko BG., Sooben RD., Thomas K, Wu J   +22 more
core   +2 more sources

Red blood cell metabolism in Down syndrome: hints on metabolic derangements in aging

Blood Advances, 2017
: Red blood cells (RBCs) are the most abundant cell in the human body. During their ∼120-day life span in the circulatory system, RBCs release oxygen to all human tissues while being exposed to tissue metabolic activity.
Rachel Culp-Hill, Connie Zheng, Julie A. Reisz, Keith Smith, Angela Rachubinski, Travis Nemkov, Eric Butcher, Ross Granrath, Kirk C. Hansen, Joaquín M. Espinosa, Angelo D'Alessandro   +10 more
doaj   +1 more source

The prevalence and incidence of mental ill-health in adults with autism and intellectual disabilities [PDF]

, 2008
The prevalence, and incidence, of mental ill-health in adults with intellectual disabilities and autism were compared with the whole population with intellectual disabilities, and with controls, matched individually for age, gender, ability-level, and ...
A. V. Brereton, Alison Jackson, B. Holden, C. Lord, C. Morgan, C. W. McGrother, Craig A. Melville, D. G. Allen, D. Mantry, Dipali Mantry, E. A. Bradley, E. A. Bradley, E. Billstedt, E. Smiley, E. Tsakanikos, E. Tsakanikos, Elita Smiley, F. Tyrer, G. Baird, G. Dawson, H. Leonard, H. Schrojenstein Lantman-de Valk van, H. W. M. Kwok, J. Bertrand, J. Hill, J. K. Kern, J. L. Matson, J. L. Matson, J. Robertson, Janet Finlayson, Jill Morrison, K. McClintock, L. Lecavalier, L. Wing, Linda Allan, M Yeargin-Allsopp, M. E. Stewart, M. G. Aman, M. Ghaziuddin, M. Ghaziuddin, M. Hotopf, M. M. Konstantareas, M. Wullink, N. Holmes, National Initiative: Autism Screening, Assessment, P. A. Filipek, P. Sturmey, P. W. Davidson, R. A. Collacott, R. Didden, R. Didden, R. Farmer, R. M. Reese, S. -A. Cooper, S. -A. Cooper, S. A. Borthwick-Duffy, S. A. Cooper, S. A. Cooper, S. Bhaumik, S. Chakrabarti, S. Chakrabarti, S. Deb, S. Moss, Sally-Ann Cooper, Scottish Intercollegiate Guideline Network, T. D. Cook, World Health Organisation, World Health Organisation   +67 more
core   +1 more source

Prevalence of Mental Health Conditions Among 6078 Individuals With Down Syndrome in the United States

Journal of Patient-Centered Research and Reviews, 2022
Findings from a recent study of the largest documented cohort of individuals with Down syndrome (DS) in the United States described prevalence of common disease conditions and strongly suggested significant disparity in mental health conditions among ...
Anne Rivelli, Veronica Fitzpatrick, Sagar Chaudhari, Laura Chicoine, Gengjie Jia, Andrey Rzhetsky, Brian Chicoine   +6 more
doaj   +1 more source

Prevalence of Endocrine Disorders Among 6078 Individuals With Down Syndrome in the United States

Journal of Patient-Centered Research and Reviews, 2022
Findings from a recent study describing prevalence of common disease conditions in the largest documented cohort of individuals with Down syndrome (DS) in the United States strongly suggested significant disparity in endocrine disorders among these ...
Anne Rivelli, Veronica Fitzpatrick, Danielle Wales, Laura Chicoine, Gengjie Jia, Andrey Rzhetsky, Brian Chicoine   +6 more
doaj   +1 more source

Prevalence of Infectious Diseases Among 6078 Individuals With Down Syndrome in the United States

Journal of Patient-Centered Research and Reviews, 2022
A recent disease prevalence study of the largest documented Down syndrome (DS) cohort in the United States strongly suggested significant disparity in general infectious disease conditions among individuals with DS versus those without DS. In this follow-
Veronica Fitzpatrick, Anne Rivelli, Sagar Chaudhari, Laura Chicoine, Gengjie Jia, Andrey Rzhetsky, Brian Chicoine   +6 more
doaj   +1 more source