Results 201 to 210 of about 11,301,930 (240)

EasyAmplicon 2: Expanding PacBio and Nanopore Long Amplicon Sequencing Analysis Pipeline for Microbiome

open access: yesAdvanced Science, EarlyView.
EasyAmplicon 2 is an updated, user‐friendly, and community‐supported pipeline designed for full‐length amplicon data from long‐read sequencing technologies such as PacBio and Nanopore. It supports multiple platforms (Illumina, PacBio, Nanopore, etc.), integrates tools like DADA2 and Emu, and offers a complete workflow from raw data processing to high ...
Hao Luo   +24 more
wiley   +1 more source

Download full issue

open access: yesMediaTropes, 2013
Matthew Tiessen, Greg Elmer
doaj  

Distinct Phage‐Encoded Enzymes for Substitution of Deoxythymidine by Deoxyuridine in Phage Genomes

open access: yesAdvanced Science, EarlyView.
Distinct enzymes including dCTP deaminases (Dcds), dTMP phosphatases (Dtms), and dTTP pyrophosphatases (Dtt) are found to be responsible for dU‐DNA biosynthesis in the phages PBS1, DSS3_VP1, and PhiR1‐37. Both PhiR1‐37‐derived and synthetic dU‐DNA are resistant to cleavage by restriction enzymes and Cas12a nuclease targeting dT‐containing sites.
Yating Li   +7 more
wiley   +1 more source

Dual Disruption of the Immune Cytokine Spätzle Facilitates Fungal Infection of Diverse Insect Hosts

open access: yesAdvanced Science, EarlyView.
The Toll pathway is essential for insect defense against fungal pathogens. This works reports that fungal parasites employ two divergent virulent effectors to target the Toll receptor ligand Spätzle: a metalloprotease degrading it and a hairpin‐like effector hijacking it to block signal transduction. This dual strategy enables the fungus to kill a wide
Shuangxiu Song   +7 more
wiley   +1 more source

ADA2 Forms Nuclear Condensates with GCN5 and ATP‐Citrate Lyase (ACL) to Modulate H3K9 Acetylation at Genes Functioning in Rice Meristems

open access: yesAdvanced Science, EarlyView.
This study unveils a novel GAA (GCN5‐ADA2‐ACL) complex that forms nuclear condensates to boost local acetyl‐CoA, facilitating histone acetylation and gene transcription in rice meristems. The research underscores the role of ADA2's disordered region in complex condensation and ACL's role in acetyl‐CoA production.
Yaping Yue   +11 more
wiley   +1 more source

NUSAP1 Recruits DAXX to Suppress HIF‐Driven Triple‐Negative Breast Cancer Progression

open access: yesAdvanced Science, EarlyView.
A double‐negative feedback loop is identified in TNBC where NUSAP1 bridges HIF and DAXX via its microtubule‐associated domain (MAD) to recruit SETDB1, repressing HIF transcriptional activity by depositing the H3K9me3 repressive mark on HIF target genes, while HIF itself suppresses NUSAP1.
Yating Du   +14 more
wiley   +1 more source

Home - About - Disclaimer - Privacy