Results 21 to 30 of about 30,894 (260)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

An optimal multiple stopping rule–based cooperative downloading scheme in vehicular cyber-physical systems

International Journal of Distributed Sensor Networks, 2017
In vehicular cyber-physical systems, vehicular users are the edge nodes which are far away from the network core. Content accessing and downloading for vehicular users are expected to heavily rely on the deployment of RoadSide Units in vehicular cyber ...
Tao Jing, Cheng Zeng, Jin Qian, Zhen Li, Yan Huo   +4 more
doaj   +1 more source

Catching the download train: Energy-efficient file downloading on smartphones

2014 26th International Teletraffic Congress (ITC), 2014
The most energy-consuming applications in battery life-constrained smartphones are the ones that comprise data transmission, especially via the 3G interface. Scheduling download activities on smartphones is especially necessary, if there are multiple asynchronous downloads scattered over a long duration.
Selim Ickin, Thomas Zinner, Katarzyna Wac, Markus Fiedler   +3 more
openaire   +3 more sources

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Smart-blacklisting:an efficient methodology for mitigating fake block attack in P2P file-sharing systems

Tongxin xuebao, 2013
Fake block attack intends to prolong the downloading time by providing fake data to make the file block fail in the hash check.P2P file-sharing systems are susceptible to fake block attacks,whereby malicious clients are able to make a big impact on users’
Ru-hao YAO, Bing-shuang LIU, De-shuai QU, Yuan ZHOU, Xin-hui HAN   +4 more
doaj   +2 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Downloading Multiple Records Using Query Strings

The Programming Historian, 2012
Downloading a single record from a website is easy, but downloading many records at a time – an increasingly frequent need for a historian – is much more efficient using a programming language such as Python.
Adam Crymble
doaj  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Coding for fast content download [PDF]

2012 50th Annual Allerton Conference on Communication, Control, and Computing (Allerton), 2012
We study the fundamental trade-off between storage and content download time. We show that the download time can be significantly reduced by dividing the content into chunks, encoding it to add redundancy and then distributing it across multiple disks. We determine the download time for two content access models - the fountain and fork-join models that
Gauri Joshi, Yanpei Liu, Emina Soljanin
openaire   +2 more sources