Results 31 to 40 of about 30,894 (260)

Interpreting the effects of DNA polymerase variants at the structural level

open access: yesMolecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi   +7 more
wiley   +1 more source

Automated Downloading with Wget

open access: yesThe Programming Historian, 2012
Wget is a useful program, run through your computer’s command line, for retrieving online material. It can be useful in the following situations: Retrieving or mirroring (creating an exact copy of) an entire website.
Ian Milligan
doaj  

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

open access: yesMolecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen   +14 more
wiley   +1 more source

Downloading Web Pages with Python

open access: yesThe Programming Historian, 2012
This lesson introduces Uniform Resource Locators (URLs) and explains how to use Python to download and save the contents of a web page to your local hard drive.
William J. Turkel, Adam Crymble
doaj  

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Non-intermittent cooperative downloading approach for VANET

open access: yesTongxin xuebao, 2016
Internet access through access points (AP) for vehicles has the advantages of low cost, high-bandwidth and low latency. However,because of dark area (DA) around AP, vehicles have to take interm tent linking to Internet, result-ing in the QoS of network ...
Yong XIE   +4 more
doaj   +2 more sources

Applied Archival Downloading with Wget

open access: yesThe Programming Historian, 2013
Archival websites offer a wealth of resources to historians, but increased accessibility does not always translate into increased utility. In other words, while online collections often allow historians to access hitherto unavailable or cost-prohibitive ...
Kellen Kurschinski
doaj  

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

open access: yesFEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui   +10 more
wiley   +1 more source

A Parser for News Downloads [PDF]

open access: yesDELTA: Documentação de Estudos em Lingüística Teórica e Aplicada, 2018
ABSTRACT This paper presents the Download Parser, a tool for handling text downloads from large online databases. Many universities have access to full-text databases which allow the user to search their holdings and then view and ideally download the full text of relevant articles, but there are important problems in practice in managing such ...
openaire   +5 more sources

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

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