Results 31 to 40 of about 52,832 (290)
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA
FEBS Open Bio, EarlyView.PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro +1 more
wiley +1 more source
Tongxin xuebao, 2013 Fake block attack intends to prolong the downloading time by providing fake data to make the file block fail in the hash check.P2P file-sharing systems are susceptible to fake block attacks,whereby malicious clients are able to make a big impact on users’
Ru-hao YAO +4 more
doaj +2 more sources
eMusic - Legal issues concerning downloading music over the Internet [PDF]
, 2014 Sharing music with friends and family has always been a popular activity. Under most copyright laws, sharing physical media with friends and family has always been seen as a 'fair use' - a set of usage patterns that have been traditionally considered to
Bechle, Thomas
core +1 more source
Journal of Informetrics, 2015 We propose a new index to quantify SSRN downloads. Unlike the SSRN downloads rank, which is based on the total number of an author's SSRN downloads, our index also reflects the author's productivity by taking into account the download numbers for the papers.
openaire +3 more sources
Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells
FEBS Open Bio, EarlyView.Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim +4 more
wiley +1 more source
Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy
FEBS Open Bio, EarlyView.This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan +11 more
wiley +1 more source
FEBS Open Bio, EarlyView.KDAC6 has been associated with cell motility and actin structures, but specific domain contributions are not established. The two catalytic domains have differential effects on motility and F‐actin regulation, affecting cortical F‐actin density, motility, stress fibers, and cell spreading.
Taylor V. Joseph +7 more
wiley +1 more source
Downloading Web Pages with Python
The Programming Historian, 2012 This lesson introduces Uniform Resource Locators (URLs) and explains how to use Python to download and save the contents of a web page to your local hard drive.
William J. Turkel, Adam Crymble
doaj
Catching the download train: Energy-efficient file downloading on smartphones
2014 26th International Teletraffic Congress (ITC), 2014 The most energy-consuming applications in battery life-constrained smartphones are the ones that comprise data transmission, especially via the 3G interface. Scheduling download activities on smartphones is especially necessary, if there are multiple asynchronous downloads scattered over a long duration.
Selim Ickin +3 more
openaire +4 more sources