Results 41 to 50 of about 52,832 (290)
Evolution‐guided yeast complementation reveals functional differences in human PSPH variants
FEBS Open Bio, EarlyView.Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez +6 more
wiley +1 more source
Religiosity and music copyright theft among Canadian Baptist youth [PDF]
, 2013 This study examines the views of 706 Canadian Baptist youth (between the ages of 14 and 18 years) on the moral issue of music copyright theft, and explores the influence on these views of age, sex, Sunday church attendance, personal prayer, personal ...
Henderson, Amanda J. +4 more
core +1 more source
Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus
FEBS Open Bio, EarlyView.BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima +7 more
wiley +1 more source
Non-intermittent cooperative downloading approach for VANET
Tongxin xuebao, 2016 Internet access through access points (AP) for vehicles has the advantages of low cost, high-bandwidth and low latency. However,because of dark area (DA) around AP, vehicles have to take interm tent linking to Internet, result-ing in the QoS of network ...
Yong XIE +4 more
doaj +2 more sources
Heterotropic regulation and negative homotropic cooperativity
FEBS Open Bio, EarlyView.We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea +5 more
wiley +1 more source
Comparative assessment of crystallographic and cryo‐EM models in the Protein Data Bank
FEBS Open Bio, EarlyView.Raw data obtained by X‐ray crystallography or cryo‐EM result in experimental maps, ultimately fitted by atomic models. Although the physical principles are different, the final results can be viewed, compared, and evaluated in the same way. With cryogenic electron microscopy (cryo‐EM) on track to surpass X‐ray crystallography as the preferred method ...
Alexander Wlodawer +7 more
wiley +1 more source
HAK MORAL PENCIPTA ATAS KARYA CIPTA YANG DIUNDUH DARI INTERNET
SASI, 2014 This paper aimed to understand the factors inhibiting legal protection for the moral rights of the author from free internet downloading and causes for difficulties in punishing downloading from internet.
Theresia N. A. Narwadan
doaj
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Isolated rapid eye movement sleep behavior disorder (iRBD) is a prodromal state for Lewy body disorders and exhibits biological heterogeneity that may influence clinical expression and progression. We examined clinical features in individuals with iRBD and biomarker‐defined synucleinopathy.
Daniel Weintraub +24 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers +19 more
wiley +1 more source
Analyzing multiple file downloading in bittorrent
, 2006 Previous studies show that more than 85 % of the peers have joined multiple torrents in BitTorrent, but theoretical work on multiple files BitTorrent downloading is rare. In this paper, we first consider the scenario of multi-torrent downloading.
Kam-wing Ng, Di Wu, Ye Tian
core +1 more source