Results 111 to 120 of about 2,123,623 (331)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Empirical support for sequential imprinting during downstream migration in Atlantic salmon (Salmo salar) smolts. [PDF]

Sci Rep, 2022
Haraldstad T, Forseth T, Olsen EM, Haugen TO, Höglund E.   +4 more
europepmc   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Downstream Migration of Burbot (Lota lota) Larvae in the Subglacial Period [PDF]

BIO Web of Conferences
The research was carried out in the Ob-Irtysh basin on the Irtysh River. The studied section of the river is located in Western Siberia in the Tyumen region.
Chemagin Andrey, Volosnikov Gleb, Drabovich Yuri   +2 more
doaj   +1 more source

Fyn-Mediated Regulation of Protein Kinase A [PDF]

, 2017
Protein kinases are enzymes important for signal transduction in the regulation of cellular processes. The cAMP-dependent protein kinase A (PKA) has been previously reported to regulate the activity of the Src family kinase Fyn, an event important for ...
Barritt, Sam
core   +1 more source

On the horseshoe drag of a low-mass planet. II Migration in adiabatic disks

, 2009
We evaluate the horseshoe drag exerted on a low-mass planet embedded in a gaseous disk, assuming the disk's flow in the coorbital region to be adiabatic.
Baruteau, Baruteau, F. S. Masset, J. Casoli, Kley, Lovelace, Masset, Masset, Masset, Masset, Tanaka, Ward, Ward   +12 more
core   +1 more source

Snail2 directly represses cadherin6B during epithelial-to-mesenchymal transitions of the neural crest [PDF]

, 2007
The neural crest, a transient population of migratory cells, forms the craniofacial skeleton and peripheral nervous system, among other derivatives in vertebrate embryos. The transcriptional repressor Snail2 is thought to be crucial for the epithelial-to-
Bronner-Fraser, Marianne, Coles, Edward G., Taneyhill, Lisa A.   +2 more
core   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Passage of fish larvae and eggs through the Funil, Itutinga and Camargos Reservoirs on the upper Rio Grande (Minas Gerais, Brazil)

Neotropical Ichthyology
The objective of this study was to evaluate the passage of fish eggs and larvae through the Funil, Itutinga and Camargos Reservoirs, located in the upper Rio Grande basin, Minas Gerais, Brazil. Samples were taken downstream and upstream of the dams using
Fábio Mineo Suzuki, Lucas Vilela Pires, Paulo Santos Pompeu   +2 more
doaj   +1 more source

Temporal progression in migratory status and sexual maturation in European silver eels during downstream migration

Fish Physiology & Biochemistry, 2011
The onset of downstream migration of European eels is accompanied by a cessation of feeding and the start of sexual maturation which stresses the link between metabolism and sexual maturation, also suggesting an important role for exercise.
A. Palstra, M. Guerrero, G. de Laak, J. G. P. Klein Breteler, G. van den Thillart   +4 more
semanticscholar   +1 more source