Results 131 to 140 of about 360,193 (299)

Targeting the Metastasis Suppressor, N-Myc Downstream Regulated Gene-1, with Novel Di-2-Pyridylketone Thiosemicarbazones: Suppression of Tumor Cell Migration and Cell-Collagen Adhesion by Inhibiting Focal Adhesion Kinase/Paxillin Signaling

, 2016
Metastasis is a complex process that is regulated by multiple signaling pathways, with the focal adhesion kinase (FAK)/paxillin pathway playing a major role in the formation of focal adhesions and cell motility.
Sahni, Sumit, Wangpu, Xiongzhi, Xi, Ruxing, Menezes, Sharleen, Huang, Michael LH, Kovacevic, Zaklina, Park, Kyung Chan, Lu, Jiaoyang, Yue, Fei, Richardson, Des R, Zheng, Minhua   +10 more
core   +1 more source

A Long‐Lived Human Neurovascular PENTA Culture Model Captures Incomplete Vascular Repair and Glia‐Associated Signaling After Traumatic Brain Injury

Advanced Healthcare Materials, EarlyView.
A long‐lived, five‐cell‐type human neurovascular (PENTA) model recreates vascular disorganization and incomplete repair after traumatic brain injury (TBI). By integrating endothelial, glial, neuronal, and immune components within a 3D scaffold, the platform enables time‐resolved analysis of neurovascular remodeling and provides a human‐relevant system ...
Daniel S. Hinrichsen, Sunghyun Jun, Colleen M. Arrasmith, Charitha C. Anamala, Mitchell D. Thielen, Anapaula Garcia, Volha Liaudanskaya   +6 more
wiley   +1 more source

Masking a fish's detection of environmental stimuli: application to improving downstream migration at river infrastructure. [PDF]

J Fish Biol, 2019
Kerr JR, Kemp PS.
europepmc   +1 more source

DOWNSTREAM MIGRATING STEPS ON ICE

Journal of Japan Society of Civil Engineers, Ser. B1 (Hydraulic Engineering), 2013
NAITO, Kensuke, IZUMI, Norihiro, YOKOKAWA, Miwa, YAMADA, Tomohito   +3 more
openaire   +2 more sources

Multidimensional Cellular Micro‐Compartments to Model Invasive Lobular Carcinoma Dormancy

Advanced Healthcare Materials, EarlyView.
Invasive lobular carcinoma (ILC) is an understudied subtype of breast cancer that is susceptible to late recurrences. In this study, micro‐compartmentalization techniques spanning multiple dimensions, including 2D, pseudo‐3D, and 3D, are integrated to uncover the mechanisms underlying ILC dormancy, revealing the central role of p27Kip1.
Xilal Y. Rima, Sarmila Majumder, Divya S. Patel, Chunyu Hu, Hong Li, Xin Huang, Kim Truc Nguyen, Jacob Doon‐Ralls, Chiranth K. Nagaraj, Mangesh D. Hade, Setty M. Magaña, Eswar Shankar, Xiaoli Zhang, Daniel G. Stover, Bhuvaneswari Ramaswamy, Eduardo Reátegui   +15 more
wiley   +1 more source

VAB-8/KIF26, LIN-17/Frizzled, and EFN-4/Ephrin control distinct stages of posterior neuroblast migration downstream of the MAB-5/Hox transcription factor in Caenorhabditis elegans.

PLoS Genetics
Hox transcription factors are involved in neuronal and neural crest development and differentiation, including migration, but the genetic programs employed by Hox genes to regulate terminal differentiation remain to be defined. In C.
Vedant D Jain, Erik A Lundquist
doaj   +1 more source

Packed for Ossification: High‐Density Bioprinting of hPDC Spheroids in HAMA Toward Endochondral Ossification

Advanced Healthcare Materials, EarlyView.
Human periosteum‐derived cell spheroids bioprinted at high density within a hyaluronic acid matrix promote fusion and hypertrophic cartilage formation in vitro. Early encapsulation enhances spheroid interaction and matrix maturation, generating scalable cartilage templates intended for endochondral bone regeneration.
Ane Albillos Sanchez, Maria Paula Marks, Paula Casademunt, Adrián Seijas‐Gamardo, Ioannis Papantoniou, Lorenzo Moroni, Carlos Mota   +6 more
wiley   +1 more source

Self‐Assembled Skin Equivalents with Monoclonal CRISPR/Cas9‐Modified N/TERT‐1 Keratinocytes: A Cutting‐Edge model for Human Skin and its Diseases

Advanced Healthcare Materials, EarlyView.
Self‐assembled, scaffold‐free full‐thickness skin equivalents with monoclonal, genetically modified N/TERT‐1 keratinocytes represent a novel in vitro model of human skin and skin diseases. The model is highly robust, reproducible, physiologically relevant, and suitable for high‐throughput applications.
Marta Slaufova, Tugay Karakaya, Michela Di Filippo, Thomas Kündig, Hans‐Dietmar Beer   +4 more
wiley   +1 more source

Mutant of PSF effects on the prolification, migration and alternative splicing

四川大学学报. 自然科学版, 2018
PSF is an important tumorsuppressor protein in eukaryotic cells. In Hela cells, PSF gene is mutant and leads to transform of its function. In order to clarify the function of PSF mutant (muPSF) in Hela cells, muPSF was knocked down by designed siRNA ...
LI Qian, AN Ting-Ting, WU Chuan-Fang
doaj  

Behavior and survival of fish migrating downstream in regulated rivers [PDF]

, 2008
Dams present obstacles to fish migrating between freshwater and marine habitats. This thesis evaluated downstream migrations of fish in five rivers in Sweden and North America, four of which were regulated (i.e., dammed). It focused on species from the subfamily Salmoninae and addressed the following questions: What is the survival of downstream ...
openaire