Results 111 to 120 of about 596,534 (308)

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Passage of fish larvae and eggs through the Funil, Itutinga and Camargos Reservoirs on the upper Rio Grande (Minas Gerais, Brazil)

Neotropical Ichthyology
The objective of this study was to evaluate the passage of fish eggs and larvae through the Funil, Itutinga and Camargos Reservoirs, located in the upper Rio Grande basin, Minas Gerais, Brazil. Samples were taken downstream and upstream of the dams using
Fábio Mineo Suzuki, Lucas Vilela Pires, Paulo Santos Pompeu   +2 more
doaj   +1 more source

MicroRNA-466 inhibits tumor growth and bone metastasis in prostate cancer by direct regulation of osteogenic transcription factor RUNX2. [PDF]

, 2017
MicroRNAs (miRNAs) have emerged as key players in cancer progression and metastatic initiation yet their importance in regulating prostate cancer (PCa) metastasis to bone has begun to be appreciated.
Colden, Melissa, Dahiya, Priya V, Dahiya, Rajvir, Dar, Altaf A, Majid, Shahana, Saini, Sharanjot, Shahryari, Varahram, Stein, Gary, Tanaka, Yuichiro, Yamamura, Soichiro   +9 more
core   +2 more sources

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

K-ras-ERK1/2 down-regulates H2A.XY142ph through WSTF to promote the progress of gastric cancer

BMC Cancer, 2019
Background Histone H2AX phosphorylation at the site of Tyr-142 can participates in multiple biological progressions, which is including DNA repair. Ras pathway is closely involved in human cancers.
Chao Dong, Jing Sun, Sha Ma, Guoying Zhang   +3 more
doaj   +1 more source

Downstream Migration and Multiple Dam Passage by Atlantic Salmon Smolts

North American Journal of Fisheries Management, 2017
Abstract The purpose of this study was to investigate behavior and survival of radio-tagged wild and hatchery-reared landlocked Atlantic Salmon Salmo salar smolts as they migrated past three hydropower dams equipped with fish bypass solutions in the Winooski River, Vermont.
D. Nyqvist, S. D. McCormick, L. Greenberg, W. R. Ardren, E. Bergman, O. Calles, T. Castro-Santos   +6 more
openaire   +2 more sources

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Next-generation optical access seamless Evolution: concluding results of the European FP7 project OASE [PDF]

, 2015
Increasing bandwidth demand drives the need for next-generation optical access (NGOA) networks that can meet future end-user service requirements.
Bianchi, Alberto, Breuer, Dirk, Chen, Jiajia, Forzati, Marco, Grobe, Klaus, Lannoo, Bart, Machuca, Carmen Mas, Point, Jean-Charles, Skubic, Bjorn, Verbrugge, Sofie, Weis, Erik, Wosinska, Lena   +11 more
core   +2 more sources

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source